Endothelial ADGRF5(GPR116) governs vascular adaptation required for sustained thermogenic remodeling of brown adipose tissue.
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| Title: | Endothelial ADGRF5(GPR116) governs vascular adaptation required for sustained thermogenic remodeling of brown adipose tissue. |
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| Authors: | El-Merahbi R; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany., Karagiannakou V; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany., Kardinal R; Biophysical Imaging, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Seep L; Life and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, Germany., Lindner R; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; Helmholtz Center Munich, Core Facility Pathology and Tissue Analytics, Germany., Jäckstein MY; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hildebrand S; Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany., Hasic M; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Korkmaz E; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany., Jha AK; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany., Krokidi AT; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany., Dyar K; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany., Meissner F; Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Grein S; Life and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, Germany., Heeren J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Klingenspor M; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Pfeifer A; Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany., Hasenauer J; Life and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, Germany., Wachten D; Biophysical Imaging, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Herzig S; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany., Georgiadi A; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany. Electronic address: anastasia.georgiadi@helmholtz-munich.de. |
| Source: | Molecular metabolism [Mol Metab] 2026 May; Vol. 107, pp. 102346. Date of Electronic Publication: 2026 Mar 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41796902 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Endothelial ADGRF5(GPR116) governs vascular adaptation required for sustained thermogenic remodeling of brown adipose tissue. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22El-Merahbi+R%22">El-Merahbi R</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Karagiannakou+V%22">Karagiannakou V</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kardinal+R%22">Kardinal R</searchLink>; Biophysical Imaging, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Seep+L%22">Seep L</searchLink>; Life and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Lindner+R%22">Lindner R</searchLink>; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; Helmholtz Center Munich, Core Facility Pathology and Tissue Analytics, Germany.<br /><searchLink fieldCode="AU" term="%22Jäckstein+MY%22">Jäckstein MY</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hildebrand+S%22">Hildebrand S</searchLink>; Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Hasic+M%22">Hasic M</searchLink>; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Korkmaz+E%22">Korkmaz E</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jha+AK%22">Jha AK</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Krokidi+AT%22">Krokidi AT</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Dyar+K%22">Dyar K</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Meissner+F%22">Meissner F</searchLink>; Systems Immunology and Proteomics, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Grein+S%22">Grein S</searchLink>; Life and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Heeren+J%22">Heeren J</searchLink>; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Klingenspor+M%22">Klingenspor M</searchLink>; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Pfeifer+A%22">Pfeifer A</searchLink>; Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Hasenauer+J%22">Hasenauer J</searchLink>; Life and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wachten+D%22">Wachten D</searchLink>; Biophysical Imaging, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Herzig+S%22">Herzig S</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Georgiadi+A%22">Georgiadi A</searchLink>; Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center Munich, Neuherberg, Germany; Helmholtz Center Munich, German Research Center for Environmental Health, Computational Health Center, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; Molecular Metabolic Control, Medical Faculty, Technical University of Munich, Germany. Electronic address: anastasia.georgiadi@helmholtz-munich.de. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101605730%22">Molecular metabolism</searchLink> [Mol Metab] 2026 May; Vol. 107, pp. 102346. <i>Date of Electronic Publication: </i>2026 Mar 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+GmbH%22">Elsevier GmbH </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101605730 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2212-8778 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222128778%22">22128778 </searchLink><i>NLM ISO Abbreviation: </i>Mol Metab <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.molmet.2026.102346 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 102346 Titles: – TitleFull: Endothelial ADGRF5(GPR116) governs vascular adaptation required for sustained thermogenic remodeling of brown adipose tissue. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: El-Merahbi R – PersonEntity: Name: NameFull: Karagiannakou V – PersonEntity: Name: NameFull: Kardinal R – PersonEntity: Name: NameFull: Seep L – PersonEntity: Name: NameFull: Lindner R – PersonEntity: Name: NameFull: Jäckstein MY – PersonEntity: Name: NameFull: Hildebrand S – PersonEntity: Name: NameFull: Hasic M – PersonEntity: Name: NameFull: Korkmaz E – PersonEntity: Name: NameFull: Jha AK – PersonEntity: Name: NameFull: Krokidi AT – PersonEntity: Name: NameFull: Dyar K – PersonEntity: Name: NameFull: Meissner F – PersonEntity: Name: NameFull: Grein S – PersonEntity: Name: NameFull: Heeren J – PersonEntity: Name: NameFull: Klingenspor M – PersonEntity: Name: NameFull: Pfeifer A – PersonEntity: Name: NameFull: Hasenauer J – PersonEntity: Name: NameFull: Wachten D – PersonEntity: Name: NameFull: Herzig S – PersonEntity: Name: NameFull: Georgiadi A IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2212-8778 Numbering: – Type: volume Value: 107 Titles: – TitleFull: Molecular metabolism Type: main |
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