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The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis.

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Title: The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis.
Authors: Wearn A; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Onuska KM; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Schmitz TW; Department of Physiology & Pharmacology, Western Institute for Neuroscience, Western University, London, Ontario, Canada., Turner GR; Department of Psychology, York University, Toronto, Ontario, Canada., Spreng RN; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, Canada.; Douglas Mental Health University Institute-Research Center, Verdun, Quebec, Canada.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Mar; Vol. 22 (3), pp. e71249.
Publication Type: Journal Article; Review
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis.
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  Data: <searchLink fieldCode="AU" term="%22Wearn+A%22">Wearn A</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Onuska+KM%22">Onuska KM</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Schmitz+TW%22">Schmitz TW</searchLink>; Department of Physiology & Pharmacology, Western Institute for Neuroscience, Western University, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Turner+GR%22">Turner GR</searchLink>; Department of Psychology, York University, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Spreng+RN%22">Spreng RN</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.; McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, Canada.; Douglas Mental Health University Institute-Research Center, Verdun, Quebec, Canada.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Mar; Vol. 22 (3), pp. e71249.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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        Value: 10.1002/alz.71249
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      – Code: eng
        Text: English
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      – TitleFull: The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis.
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              Text: 2026 Mar
              Type: published
              Y: 2026
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