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Globo H ceramide confers chemoresistance and poor prognosis to advanced gallbladder cancer via A2AR/cAMP/PKA pathway.

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Title: Globo H ceramide confers chemoresistance and poor prognosis to advanced gallbladder cancer via A2AR/cAMP/PKA pathway.
Authors: Hung TH; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Hung JT; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Huang WK; Department of Hematology-Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan., Huang Y; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; School of medicine, National Tsing Hua University, Hsinchu, Taiwan., Wu CE; Department of Hematology-Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan., Cheng JY; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Lee CW; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Yu J; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Chang Gung University, Taoyuan, Taiwan., Wu YC; Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan., Yeh CN; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; School of medicine, National Tsing Hua University, Hsinchu, Taiwan.; Chang Gung University, Taoyuan, Taiwan.; Department of Surgery and Liver Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan., Yu AL; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Chang Gung University, Taoyuan, Taiwan.; Department of Pediatrics, University of California in San Diego, San Diego, CA 92103, USA.
Source: Theranostics [Theranostics] 2026 Feb 26; Vol. 16 (9), pp. 4940-4958. Date of Electronic Publication: 2026 Feb 26 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
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  Data: Globo H ceramide confers chemoresistance and poor prognosis to advanced gallbladder cancer via A2AR/cAMP/PKA pathway.
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  Data: <searchLink fieldCode="AU" term="%22Hung+TH%22">Hung TH</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+JT%22">Hung JT</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+WK%22">Huang WK</searchLink>; Department of Hematology-Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; School of medicine, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+CE%22">Wu CE</searchLink>; Department of Hematology-Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+JY%22">Cheng JY</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+CW%22">Lee CW</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YC%22">Wu YC</searchLink>; Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+CN%22">Yeh CN</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; School of medicine, National Tsing Hua University, Hsinchu, Taiwan.; Chang Gung University, Taoyuan, Taiwan.; Department of Surgery and Liver Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+AL%22">Yu AL</searchLink>; Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Chang Gung University, Taoyuan, Taiwan.; Department of Pediatrics, University of California in San Diego, San Diego, CA 92103, USA.
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  Data: <searchLink fieldCode="JN" term="%22101552395%22">Theranostics</searchLink> [Theranostics] 2026 Feb 26; Vol. 16 (9), pp. 4940-4958. <i>Date of Electronic Publication: </i>2026 Feb 26 (<i>Print Publication: </i>2026).
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