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Betulinic acid increases brain-derived neurotrophic factor expression via the PKA, NMDA receptor, and calcineurin pathways in cultured cortical neurons.

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Title: Betulinic acid increases brain-derived neurotrophic factor expression via the PKA, NMDA receptor, and calcineurin pathways in cultured cortical neurons.
Authors: Fukuchi M; Laboratory of Molecular Neuroscience, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan. fukuchi@takasaki-u.ac.jp., Maeda N; Laboratory of Molecular Neuroscience, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan., Hoshino S; Laboratory of Natural Medicines, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan., Huanood G; Laboratory of Molecular Neuroscience, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan., Watanabe K; Laboratory of Natural Medicines, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan.
Source: Journal of natural medicines [J Nat Med] 2026 May; Vol. 80 (3), pp. 735-747. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Japan NLM ID: 101518405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1861-0293 (Electronic) Linking ISSN: 13403443 NLM ISO Abbreviation: J Nat Med Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Betulinic acid increases brain-derived neurotrophic factor expression via the PKA, NMDA receptor, and calcineurin pathways in cultured cortical neurons.
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  Data: <searchLink fieldCode="AU" term="%22Fukuchi+M%22">Fukuchi M</searchLink>; Laboratory of Molecular Neuroscience, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan. fukuchi@takasaki-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Maeda+N%22">Maeda N</searchLink>; Laboratory of Molecular Neuroscience, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan.<br /><searchLink fieldCode="AU" term="%22Hoshino+S%22">Hoshino S</searchLink>; Laboratory of Natural Medicines, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan.<br /><searchLink fieldCode="AU" term="%22Huanood+G%22">Huanood G</searchLink>; Laboratory of Molecular Neuroscience, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+K%22">Watanabe K</searchLink>; Laboratory of Natural Medicines, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui-machi, Takasaki, Gunma, 370-0033, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101518405%22">Journal of natural medicines</searchLink> [J Nat Med] 2026 May; Vol. 80 (3), pp. 735-747. <i>Date of Electronic Publication: </i>2026 Mar 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Japan <i>NLM ID: </i>101518405 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1861-0293 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213403443%22">13403443 </searchLink><i>NLM ISO Abbreviation: </i>J Nat Med <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.1007/s11418-026-02025-6
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              Text: 2026 May
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