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Impact of proton pump inhibitors on immunotherapy is modulated by prior chemotherapy and linked to gut microbiome-immune cell signatures.

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Title: Impact of proton pump inhibitors on immunotherapy is modulated by prior chemotherapy and linked to gut microbiome-immune cell signatures.
Authors: Petouhoff A; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Hicks R; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Husain M; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Hoyd R; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Xu M; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Dravillas C; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Patel SH; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Johns A; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Grogan M; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Li M; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA., Lopez G; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Miah A; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Liu Y; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Muniak M; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Schmidt M; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Das A; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Lathrop H; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Das P; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Secor A; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Haddad T; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Tinoco G; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA., Carbone D; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, 460 W 12th Ave, Columbus, OH, 43210, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA., Kendra K; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA., Otterson GA; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA., Presley CJ; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA., Mace T; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, 420 W. 12th Ave, OH, 43210, Columbus, USA., Spakowicz D; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Daniel.Spakowicz@osumc.edu.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, 460 W 12th Ave, Columbus, OH, 43210, USA. Daniel.Spakowicz@osumc.edu.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA. Daniel.Spakowicz@osumc.edu., Owen DH; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Dwight.Owen@osumc.edu.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, 460 W 12th Ave, Columbus, OH, 43210, USA. Dwight.Owen@osumc.edu.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA. Dwight.Owen@osumc.edu.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Mar 09; Vol. 75 (4). Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of proton pump inhibitors on immunotherapy is modulated by prior chemotherapy and linked to gut microbiome-immune cell signatures.
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  Data: <searchLink fieldCode="AU" term="%22Petouhoff+A%22">Petouhoff A</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hicks+R%22">Hicks R</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Husain+M%22">Husain M</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hoyd+R%22">Hoyd R</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Dravillas+C%22">Dravillas C</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Patel+SH%22">Patel SH</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Johns+A%22">Johns A</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Grogan+M%22">Grogan M</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Lopez+G%22">Lopez G</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Miah+A%22">Miah A</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Muniak+M%22">Muniak M</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+M%22">Schmidt M</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Das+A%22">Das A</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lathrop+H%22">Lathrop H</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Das+P%22">Das P</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Secor+A%22">Secor A</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Haddad+T%22">Haddad T</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Tinoco+G%22">Tinoco G</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Carbone+D%22">Carbone D</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, 460 W 12th Ave, Columbus, OH, 43210, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Kendra+K%22">Kendra K</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Otterson+GA%22">Otterson GA</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Presley+CJ%22">Presley CJ</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Mace+T%22">Mace T</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, 420 W. 12th Ave, OH, 43210, Columbus, USA.<br /><searchLink fieldCode="AU" term="%22Spakowicz+D%22">Spakowicz D</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Daniel.Spakowicz@osumc.edu.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, 460 W 12th Ave, Columbus, OH, 43210, USA. Daniel.Spakowicz@osumc.edu.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA. Daniel.Spakowicz@osumc.edu.<br /><searchLink fieldCode="AU" term="%22Owen+DH%22">Owen DH</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Dwight.Owen@osumc.edu.; Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, 460 W 12th Ave, Columbus, OH, 43210, USA. Dwight.Owen@osumc.edu.; Division of Medical Oncology, Department of Internal Medicine, 1800 Cannon Drive, Suite 1335, Columbus, OH, 43210, USA. Dwight.Owen@osumc.edu.
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