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Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice.

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Title: Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice.
Authors: Volf A; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA.; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA., Brust TF; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA., Kobylski RR; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA.; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA., Czekner KM; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Florida, FL, USA., Stahl EL; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Florida, FL, USA., Cameron MD; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA., Trojniak AE; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wood AB; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Aubé J; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. JAube@email.UNC.edu., Bohn LM; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA. LBohn@usf.edu.; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Florida, FL, USA. LBohn@usf.edu.
Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2026 Jul; Vol. 51 (8), pp. 1485-1496. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
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  Data: Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice.
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  Data: <searchLink fieldCode="AU" term="%22Volf+A%22">Volf A</searchLink>; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA.; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.<br /><searchLink fieldCode="AU" term="%22Brust+TF%22">Brust TF</searchLink>; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kobylski+RR%22">Kobylski RR</searchLink>; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA.; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.<br /><searchLink fieldCode="AU" term="%22Czekner+KM%22">Czekner KM</searchLink>; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Florida, FL, USA.<br /><searchLink fieldCode="AU" term="%22Stahl+EL%22">Stahl EL</searchLink>; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Florida, FL, USA.<br /><searchLink fieldCode="AU" term="%22Cameron+MD%22">Cameron MD</searchLink>; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA.<br /><searchLink fieldCode="AU" term="%22Trojniak+AE%22">Trojniak AE</searchLink>; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wood+AB%22">Wood AB</searchLink>; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Aubé+J%22">Aubé J</searchLink>; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. JAube@email.UNC.edu.<br /><searchLink fieldCode="AU" term="%22Bohn+LM%22">Bohn LM</searchLink>; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA. LBohn@usf.edu.; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Florida, FL, USA. LBohn@usf.edu.
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  Data: <searchLink fieldCode="JN" term="%228904907%22">Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology</searchLink> [Neuropsychopharmacology] 2026 Jul; Vol. 51 (8), pp. 1485-1496. <i>Date of Electronic Publication: </i>2026 Mar 09.
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              Text: 2026 Jul
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