Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice.
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| Title: | Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice. |
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| Authors: | Volf A; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA.; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA., Brust TF; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA., Kobylski RR; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA.; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA., Czekner KM; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Florida, FL, USA., Stahl EL; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Florida, FL, USA., Cameron MD; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA., Trojniak AE; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wood AB; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Aubé J; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. JAube@email.UNC.edu., Bohn LM; The Skaggs Graduate School at Scripps Research, La Jolla, FL, USA. LBohn@usf.edu.; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Florida, FL, USA. LBohn@usf.edu. |
| Source: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2026 Jul; Vol. 51 (8), pp. 1485-1496. Date of Electronic Publication: 2026 Mar 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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