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Glucocorticoids suppress early lung inflammation and impair control of SARS-CoV-2 in non-human primates.

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Title: Glucocorticoids suppress early lung inflammation and impair control of SARS-CoV-2 in non-human primates.
Authors: Nelson CE; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Kauffman KD; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Sakai S; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Newbolt T; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Buchanan J; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Foreman TW; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Walker AM; Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Gomez F; Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Fleegle JD; Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Herbert R; Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Hill T; Integrated Data Science Section, Research Technologies Branch, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Turan S; Leidos Biomedical Sciences Inc, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America., Mayer-Barber KD; Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Johnson RF; SARS-CoV-2 Virology Core, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Via LE; Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America., Barber DL; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Corporate Authors: Tuberculosis Imaging Program
Source: PloS one [PLoS One] 2026 Mar 10; Vol. 21 (3), pp. e0342849. Date of Electronic Publication: 2026 Mar 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Nelson+CE%22">Nelson CE</searchLink>; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Kauffman+KD%22">Kauffman KD</searchLink>; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Sakai+S%22">Sakai S</searchLink>; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Newbolt+T%22">Newbolt T</searchLink>; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Buchanan+J%22">Buchanan J</searchLink>; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Foreman+TW%22">Foreman TW</searchLink>; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Walker+AM%22">Walker AM</searchLink>; Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Gomez+F%22">Gomez F</searchLink>; Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Fleegle+JD%22">Fleegle JD</searchLink>; Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Herbert+R%22">Herbert R</searchLink>; Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Hill+T%22">Hill T</searchLink>; Integrated Data Science Section, Research Technologies Branch, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Turan+S%22">Turan S</searchLink>; Leidos Biomedical Sciences Inc, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Mayer-Barber+KD%22">Mayer-Barber KD</searchLink>; Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Johnson+RF%22">Johnson RF</searchLink>; SARS-CoV-2 Virology Core, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Via+LE%22">Via LE</searchLink>; Tuberculosis Imaging Program, Division of Intramural Research, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Barber+DL%22">Barber DL</searchLink>; T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
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