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Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells.

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Title: Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells.
Authors: Kamaraj US; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Chen Y; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Lei J; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Gautam P; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Horcharoensuk P; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Physiology, NUS Yong Loo Lin School of Medicine, Singapore, Singapore., Clemente CKM; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Weinacht KG; Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford University, Stanford, CA, USA., Gascoigne NRJ; Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Cancer Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Graduate School's Integrative Sciences and Engineering Programme, National University of Singapore, Singapore, Singapore., Chen J; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Immunology Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chen CK; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Cardiology, Department of Paediatrics, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Chen Q; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Li QJ; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ng LG; Shanghai Immune Therapy Institute, School of Medicine, Shanghai Jiao Tong University, Renji Hospital, Shanghai, China., Loh YH; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore. Jonathan_LOH@a-star.edu.sg.; Department of Physiology, NUS Yong Loo Lin School of Medicine, Singapore, Singapore. Jonathan_LOH@a-star.edu.sg.; NUS Graduate School's Integrative Sciences and Engineering Programme, National University of Singapore, Singapore, Singapore. Jonathan_LOH@a-star.edu.sg.; Department of Biological Sciences, National University of Singapore, Singapore, Singapore. Jonathan_LOH@a-star.edu.sg.
Source: Nature communications [Nat Commun] 2026 Mar 10; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Kamaraj+US%22">Kamaraj US</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Lei+J%22">Lei J</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Gautam+P%22">Gautam P</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Horcharoensuk+P%22">Horcharoensuk P</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Physiology, NUS Yong Loo Lin School of Medicine, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Clemente+CKM%22">Clemente CKM</searchLink>; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Weinacht+KG%22">Weinacht KG</searchLink>; Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gascoigne+NRJ%22">Gascoigne NRJ</searchLink>; Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Cancer Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Graduate School's Integrative Sciences and Engineering Programme, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Immunology Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+CK%22">Chen CK</searchLink>; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Cardiology, Department of Paediatrics, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+QJ%22">Li QJ</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+LG%22">Ng LG</searchLink>; Shanghai Immune Therapy Institute, School of Medicine, Shanghai Jiao Tong University, Renji Hospital, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Loh+YH%22">Loh YH</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore. Jonathan_LOH@a-star.edu.sg.; Department of Physiology, NUS Yong Loo Lin School of Medicine, Singapore, Singapore. Jonathan_LOH@a-star.edu.sg.; NUS Graduate School's Integrative Sciences and Engineering Programme, National University of Singapore, Singapore, Singapore. Jonathan_LOH@a-star.edu.sg.; Department of Biological Sciences, National University of Singapore, Singapore, Singapore. Jonathan_LOH@a-star.edu.sg.
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