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Development of an integrated physiologically based toxicokinetic-toxicodynamic model for quantitative prediction of polyhexamethylene guanidine-induced human toxicity.

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Title: Development of an integrated physiologically based toxicokinetic-toxicodynamic model for quantitative prediction of polyhexamethylene guanidine-induced human toxicity.
Authors: Jang JH; College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk- gu, Gwangju, 61186, Republic of Korea., Park DH; Department of Biomedical Science, Sunchon National University, 255 Jungang-ro, Suncheon-si, Jeollanam-do, 57922, Republic of Korea., Kim JJ; Department of Biomedical Science, Sunchon National University, 255 Jungang-ro, Suncheon-si, Jeollanam-do, 57922, Republic of Korea., Park YJ; College of Pharmacy, Kyungsung University, Busan, 48434, South Korea., Chung KH; College of Pharmacy, Kyungsung University, Busan, 48434, South Korea.; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, South Korea., Kim HJ; Humidifier Disinfectant Health Center, Environmental Health Research Department, National Institute of Environmental Research, Incheon, South Korea., Kim H; Humidifier Disinfectant Health Center, Environmental Health Research Department, National Institute of Environmental Research, Incheon, South Korea., Jeong SH; College of Pharmacy, Sunchon National University, 255 Jungang-ro, Suncheon-si, Jeollanam-do, 57922, Republic of Korea. jeongsh@scnu.ac.kr.; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon-si, 57922, Republic of Korea. jeongsh@scnu.ac.kr.
Source: Archives of toxicology [Arch Toxicol] 2026 Jun; Vol. 100 (6), pp. 2615-2628. Date of Electronic Publication: 2026 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Development of an integrated physiologically based toxicokinetic-toxicodynamic model for quantitative prediction of polyhexamethylene guanidine-induced human toxicity.
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  Data: <searchLink fieldCode="AU" term="%22Jang+JH%22">Jang JH</searchLink>; College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk- gu, Gwangju, 61186, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+DH%22">Park DH</searchLink>; Department of Biomedical Science, Sunchon National University, 255 Jungang-ro, Suncheon-si, Jeollanam-do, 57922, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JJ%22">Kim JJ</searchLink>; Department of Biomedical Science, Sunchon National University, 255 Jungang-ro, Suncheon-si, Jeollanam-do, 57922, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+YJ%22">Park YJ</searchLink>; College of Pharmacy, Kyungsung University, Busan, 48434, South Korea.<br /><searchLink fieldCode="AU" term="%22Chung+KH%22">Chung KH</searchLink>; College of Pharmacy, Kyungsung University, Busan, 48434, South Korea.; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+HJ%22">Kim HJ</searchLink>; Humidifier Disinfectant Health Center, Environmental Health Research Department, National Institute of Environmental Research, Incheon, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Humidifier Disinfectant Health Center, Environmental Health Research Department, National Institute of Environmental Research, Incheon, South Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+SH%22">Jeong SH</searchLink>; College of Pharmacy, Sunchon National University, 255 Jungang-ro, Suncheon-si, Jeollanam-do, 57922, Republic of Korea. jeongsh@scnu.ac.kr.; College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon-si, 57922, Republic of Korea. jeongsh@scnu.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2026 Jun; Vol. 100 (6), pp. 2615-2628. <i>Date of Electronic Publication: </i>2026 Mar 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0417615 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0738 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203405761%22">03405761 </searchLink><i>NLM ISO Abbreviation: </i>Arch Toxicol <i>Subsets: </i>MEDLINE; In Process
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      – Type: doi
        Value: 10.1007/s00204-026-04335-w
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      – Code: eng
        Text: English
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        StartPage: 2615
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            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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