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Constitutive EGFR Activation Induced by PTPRR Downregulation Confers Resistance to KRAS Inhibitors.

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Title: Constitutive EGFR Activation Induced by PTPRR Downregulation Confers Resistance to KRAS Inhibitors.
Authors: Kanemura H; Department of Medical Oncology, Kindai University Faculty of Medicine, Sakai, Japan., Takehara T; Division of Cell Biology for Regenerative Medicine, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Sakai, Japan., Maenishi O; Department of Pathology, Kindai University Faculty of Medicine, Sakai, Japan., Tomida S; Center for Comprehensive Genomic Medicine, Okayama University Hospital, Okayama, Japan., Iwawaki N; Division of Cell Biology for Regenerative Medicine, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Sakai, Japan., Kunimasa K; Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan., Nakayama T; Department of Medical Oncology, Kishiwada City Hospital, Kishiwada, Japan., Watanabe S; Department of Medical Oncology, Kishiwada City Hospital, Kishiwada, Japan., Suzuki S; Department of Medical Oncology, Kindai University Faculty of Medicine, Sakai, Japan., Sakai K; Department of Genome Biology, Kindai University Faculty of Medicine, Sakai, Japan.; Center for Genomics, Life Science Research Institute, Kindai University, Sakai, Japan., Azuma K; Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan., Kudo K; Department of Medical Oncology, National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Japan., Nishio K; Department of Genome Biology, Kindai University Faculty of Medicine, Sakai, Japan.; Center for Genomics, Life Science Research Institute, Kindai University, Sakai, Japan., Nakagawa K; Department of Medical Oncology, Kindai University Faculty of Medicine, Sakai, Japan., Hayashi H; Department of Medical Oncology, Kindai University Faculty of Medicine, Sakai, Japan., Teramura T; Division of Cell Biology for Regenerative Medicine, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Sakai, Japan., Yonesaka K; Department of Medical Oncology, Kindai University Faculty of Medicine, Sakai, Japan.
Source: Cancer research communications [Cancer Res Commun] 2026 Apr 01; Vol. 6 (4), pp. 728-741.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE
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  Data: Constitutive EGFR Activation Induced by PTPRR Downregulation Confers Resistance to KRAS Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Kanemura+H%22">Kanemura H</searchLink>; Department of Medical Oncology, Kindai University Faculty of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Takehara+T%22">Takehara T</searchLink>; Division of Cell Biology for Regenerative Medicine, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Maenishi+O%22">Maenishi O</searchLink>; Department of Pathology, Kindai University Faculty of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Tomida+S%22">Tomida S</searchLink>; Center for Comprehensive Genomic Medicine, Okayama University Hospital, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Iwawaki+N%22">Iwawaki N</searchLink>; Division of Cell Biology for Regenerative Medicine, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Kunimasa+K%22">Kunimasa K</searchLink>; Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nakayama+T%22">Nakayama T</searchLink>; Department of Medical Oncology, Kishiwada City Hospital, Kishiwada, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+S%22">Watanabe S</searchLink>; Department of Medical Oncology, Kishiwada City Hospital, Kishiwada, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+S%22">Suzuki S</searchLink>; Department of Medical Oncology, Kindai University Faculty of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Sakai+K%22">Sakai K</searchLink>; Department of Genome Biology, Kindai University Faculty of Medicine, Sakai, Japan.; Center for Genomics, Life Science Research Institute, Kindai University, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Azuma+K%22">Azuma K</searchLink>; Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.<br /><searchLink fieldCode="AU" term="%22Kudo+K%22">Kudo K</searchLink>; Department of Medical Oncology, National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Japan.<br /><searchLink fieldCode="AU" term="%22Nishio+K%22">Nishio K</searchLink>; Department of Genome Biology, Kindai University Faculty of Medicine, Sakai, Japan.; Center for Genomics, Life Science Research Institute, Kindai University, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagawa+K%22">Nakagawa K</searchLink>; Department of Medical Oncology, Kindai University Faculty of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Hayashi+H%22">Hayashi H</searchLink>; Department of Medical Oncology, Kindai University Faculty of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Teramura+T%22">Teramura T</searchLink>; Division of Cell Biology for Regenerative Medicine, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Yonesaka+K%22">Yonesaka K</searchLink>; Department of Medical Oncology, Kindai University Faculty of Medicine, Sakai, Japan.
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  Data: <searchLink fieldCode="JN" term="%229918281580506676%22">Cancer research communications</searchLink> [Cancer Res Commun] 2026 Apr 01; Vol. 6 (4), pp. 728-741.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918281580506676 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2767-9764 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227679764%22">27679764 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res Commun <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 01
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