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Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway.

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Title: Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway.
Authors: Xu ZR; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Wu K; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Guo RY; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Wang P; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Ou-Yang JW; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Cao ZQ; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Yang HC; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Kim JH; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea., Zhang XH; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Suk K; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea., Zhen XC; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China., Wang Y; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. yuanw@suda.edu.cn., Du XD; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. xiangdong-du@163.com., Zheng LT; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. zhenglongtai@suda.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jul; Vol. 47 (7), pp. 1749-1764. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway.
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  Data: <searchLink fieldCode="AU" term="%22Xu+ZR%22">Xu ZR</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Wu+K%22">Wu K</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Guo+RY%22">Guo RY</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Ou-Yang+JW%22">Ou-Yang JW</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Cao+ZQ%22">Cao ZQ</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Yang+HC%22">Yang HC</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Kim+JH%22">Kim JH</searchLink>; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Zhang+XH%22">Zhang XH</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Suk+K%22">Suk K</searchLink>; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Zhen+XC%22">Zhen XC</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. yuanw@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Du+XD%22">Du XD</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. xiangdong-du@163.com.<br /><searchLink fieldCode="AU" term="%22Zheng+LT%22">Zheng LT</searchLink>; The Affiliated Guangji Hospital of Soochow University, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China. zhenglongtai@suda.edu.cn.
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        Value: 10.1038/s41401-026-01777-x
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        Text: English
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              Text: 2026 Jul
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