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TSPO governs bone-lipid homeostasis by redirecting BMSC differentiation via the PI3K/AKT/β-catenin pathway.

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Title: TSPO governs bone-lipid homeostasis by redirecting BMSC differentiation via the PI3K/AKT/β-catenin pathway.
Authors: Zhang P; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China., Zheng H; Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441021, Hubei, China., Lin Z; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China., Zhang M; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China., Yang L; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China., Deng Z; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China., Song C; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China., Dai H; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China., Su Y; Department of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China., Zhang R; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China., Yu G; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China., Luo J; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China., Xu J; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China. jiexud@126.com.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China. jiexud@126.com.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China. jiexud@126.com.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China. jiexud@126.com., Luo F; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China. 32311106@qq.com.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China. 32311106@qq.com.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China. 32311106@qq.com.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China. 32311106@qq.com.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 Mar 11; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TSPO governs bone-lipid homeostasis by redirecting BMSC differentiation via the PI3K/AKT/β-catenin pathway.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.<br /><searchLink fieldCode="AU" term="%22Zheng+H%22">Zheng H</searchLink>; Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441021, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Lin+Z%22">Lin Z</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.<br /><searchLink fieldCode="AU" term="%22Deng+Z%22">Deng Z</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.<br /><searchLink fieldCode="AU" term="%22Song+C%22">Song C</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China.<br /><searchLink fieldCode="AU" term="%22Dai+H%22">Dai H</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.<br /><searchLink fieldCode="AU" term="%22Su+Y%22">Su Y</searchLink>; Department of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.<br /><searchLink fieldCode="AU" term="%22Yu+G%22">Yu G</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China. jiexud@126.com.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China. jiexud@126.com.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China. jiexud@126.com.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China. jiexud@126.com.<br /><searchLink fieldCode="AU" term="%22Luo+F%22">Luo F</searchLink>; Shengli Clinical Medical College, Fujian Medical University, Fuzhou, 350001, China. 32311106@qq.com.; Department of Orthopedics, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China. 32311106@qq.com.; Clinical Center of Orthopedics and Sports Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China. 32311106@qq.com.; Fujian Provincial Clinical Research Center for Spine, Nerve and Joint Diseases, Fuzhou, 350001, China. 32311106@qq.com.
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  Data: <searchLink fieldCode="JN" term="%22101527581%22">Stem cell research & therapy</searchLink> [Stem Cell Res Ther] 2026 Mar 11; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101527581 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-6512 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217576512%22">17576512 </searchLink><i>NLM ISO Abbreviation: </i>Stem Cell Res Ther <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41814363
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        Value: 10.1186/s13287-026-04948-z
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              Text: 2026 Mar 11
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