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Liver metastases in advanced urothelial carcinoma (ARON-2): do pembrolizumab and avelumab make a difference in a poor-prognosis scenario?

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Title: Liver metastases in advanced urothelial carcinoma (ARON-2): do pembrolizumab and avelumab make a difference in a poor-prognosis scenario?
Authors: Cerbone L; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), National Cancer Institute Regina Elena, Rome, Italy., Roviello G; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy., Calabrò F; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), National Cancer Institute Regina Elena, Rome, Italy., Taha T; The Royal Marsden National Health Service (NHS) Foundation Trust, The Institute of Cancer Research, London, United Kingdom., Grande E; Department of Medical Oncology, MD Anderson Cancer Center Madrid, Madrid, Spain., Binz K; Division of Medical Oncology, Department of Internal Medicine, University of Kansas Cancer Center, Kansas City, KS, United States., Kanesvaran R; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Pirstuk A; Department of Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia., Fiala O; Department of Oncology and Radiotherapeutics, Faculty of Medicine and University Hospital in Pilsen, Charles University, Pilsen, Czechia.; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia., Molina-Cerrillo J; Department of Medical Oncology, Hospital Ramón y Cajal, Madrid, Spain., Alonso-Gordoa T; Department of Medical Oncology, Hospital Ramón y Cajal, Madrid, Spain., Rizzo A; S.S.D. C.O.r.O. Bed Management Presa in Carico, TDM, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori 'Giovanni Paolo II,', Bari, Italy., Pichler R; Department of Urology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria., Myint ZW; Division of Medical Oncology, Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington, KY, United States., Poprach A; Masaryk Memorial Cancer Institute, Masaryk University, Brno, Czechia., Facchini G; Oncology Operative Unit, Santa Maria delle Grazie Hospital, Azienda Sanitaria Locale (ASL) NA2 NORD, P, ozzuoli, Napoli, Italy., Bohuslav M; Department of Oncology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czechia., Studentova H; Department of Oncology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czechia., Morelli F; Medical Oncology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, Foggia, Italy., Buchler T; Department of Oncology, Charles University and University Hospital Motol, Prague, Czechia., Mennitto A; Department of Medical Oncology, Azienda Ospedaliera Universitaria 'Maggiore Della Carità,', Novara, Italy., Tural D; Department of Medical Oncology, Koc University Medical Faculty, Istanbul, Türkiye., Formisano L; Department of Medicine and Surgery, Federico II University, Naples, Italy., Orejana I; Department of Medical Oncology, MD Anderson Cancer Center Madrid, Madrid, Spain., Catalano M; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy., Buti S; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.; Department of Medicine and Surgery, University of Parma, Parma, Italy., Monteiro FSM; Oncology and Hematology Department, Hospital Sírio Libanês, Brasília, Brazil.; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil., Soares A; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.; Oncology Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil., Gupta S; Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, United States., Massari F; Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy., Santoni M; Medical Oncology Unit, Macerata Hospital, Macerata, Italy.
Source: Frontiers in immunology [Front Immunol] 2026 Feb 24; Vol. 17, pp. 1667155. Date of Electronic Publication: 2026 Feb 24 (Print Publication: 2026).
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Liver metastases in advanced urothelial carcinoma (ARON-2): do pembrolizumab and avelumab make a difference in a poor-prognosis scenario?
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  Data: <searchLink fieldCode="AU" term="%22Cerbone+L%22">Cerbone L</searchLink>; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), National Cancer Institute Regina Elena, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Roviello+G%22">Roviello G</searchLink>; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Calabrò+F%22">Calabrò F</searchLink>; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), National Cancer Institute Regina Elena, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Taha+T%22">Taha T</searchLink>; The Royal Marsden National Health Service (NHS) Foundation Trust, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Grande+E%22">Grande E</searchLink>; Department of Medical Oncology, MD Anderson Cancer Center Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Binz+K%22">Binz K</searchLink>; Division of Medical Oncology, Department of Internal Medicine, University of Kansas Cancer Center, Kansas City, KS, United States.<br /><searchLink fieldCode="AU" term="%22Kanesvaran+R%22">Kanesvaran R</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Pirstuk+A%22">Pirstuk A</searchLink>; Department of Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia.<br /><searchLink fieldCode="AU" term="%22Fiala+O%22">Fiala O</searchLink>; Department of Oncology and Radiotherapeutics, Faculty of Medicine and University Hospital in Pilsen, Charles University, Pilsen, Czechia.; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.<br /><searchLink fieldCode="AU" term="%22Molina-Cerrillo+J%22">Molina-Cerrillo J</searchLink>; Department of Medical Oncology, Hospital Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alonso-Gordoa+T%22">Alonso-Gordoa T</searchLink>; Department of Medical Oncology, Hospital Ramón y Cajal, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rizzo+A%22">Rizzo A</searchLink>; S.S.D. 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Bed Management Presa in Carico, TDM, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori 'Giovanni Paolo II,', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Pichler+R%22">Pichler R</searchLink>; Department of Urology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Myint+ZW%22">Myint ZW</searchLink>; Division of Medical Oncology, Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington, KY, United States.<br /><searchLink fieldCode="AU" term="%22Poprach+A%22">Poprach A</searchLink>; Masaryk Memorial Cancer Institute, Masaryk University, Brno, Czechia.<br /><searchLink fieldCode="AU" term="%22Facchini+G%22">Facchini G</searchLink>; Oncology Operative Unit, Santa Maria delle Grazie Hospital, Azienda Sanitaria Locale (ASL) NA2 NORD, P, ozzuoli, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Bohuslav+M%22">Bohuslav M</searchLink>; Department of Oncology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czechia.<br /><searchLink fieldCode="AU" term="%22Studentova+H%22">Studentova H</searchLink>; Department of Oncology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czechia.<br /><searchLink fieldCode="AU" term="%22Morelli+F%22">Morelli F</searchLink>; Medical Oncology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Buchler+T%22">Buchler T</searchLink>; Department of Oncology, Charles University and University Hospital Motol, Prague, Czechia.<br /><searchLink fieldCode="AU" term="%22Mennitto+A%22">Mennitto A</searchLink>; Department of Medical Oncology, Azienda Ospedaliera Universitaria 'Maggiore Della Carità,', Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Tural+D%22">Tural D</searchLink>; Department of Medical Oncology, Koc University Medical Faculty, Istanbul, Türkiye.<br /><searchLink fieldCode="AU" term="%22Formisano+L%22">Formisano L</searchLink>; Department of Medicine and Surgery, Federico II University, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Orejana+I%22">Orejana I</searchLink>; Department of Medical Oncology, MD Anderson Cancer Center Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Catalano+M%22">Catalano M</searchLink>; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Buti+S%22">Buti S</searchLink>; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.; Department of Medicine and Surgery, University of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Monteiro+FSM%22">Monteiro FSM</searchLink>; Oncology and Hematology Department, Hospital Sírio Libanês, Brasília, Brazil.; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Soares+A%22">Soares A</searchLink>; Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.; Oncology Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Gupta+S%22">Gupta S</searchLink>; Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Massari+F%22">Massari F</searchLink>; Medical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Santoni+M%22">Santoni M</searchLink>; Medical Oncology Unit, Macerata Hospital, Macerata, Italy.
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