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Early administration of renin-angiotensin system inhibitors improves survival and cardiac remodeling in heart failure with preserved ejection fraction.

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Title: Early administration of renin-angiotensin system inhibitors improves survival and cardiac remodeling in heart failure with preserved ejection fraction.
Authors: Kono Y; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan.; Collage of Human Life and Environment, Kinjo Gakuin University, Nagoya-shi, Aichi, Japan., Sonoda K; Collage of Human Life and Environment, Kinjo Gakuin University, Nagoya-shi, Aichi, Japan., Ohtake K; School of Pharmacy, Faculty of Pharmaceutical Science, Josai University, Sakado-shi, Saitama, Japan., Ota A; Collage of Human Life and Environment, Kinjo Gakuin University, Nagoya-shi, Aichi, Japan., Yamamoto S; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan.; Academic Field of Health Science, Okayama University, Okayama-shi, Okayama, Japan., Nakayama H; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan., Fukuoka T; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan., Kawai Y; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan., Tago H; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan., Watanabe N; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan., Sato I; Academic Field of Health Science, Okayama University, Okayama-shi, Okayama, Japan., Hirohata S; Academic Field of Health Science, Okayama University, Okayama-shi, Okayama, Japan., Kitamori K; Collage of Human Life and Environment, Kinjo Gakuin University, Nagoya-shi, Aichi, Japan., Watanabe S; Academic Field of Health Science, Okayama University, Okayama-shi, Okayama, Japan.
Source: PloS one [PLoS One] 2026 Mar 12; Vol. 21 (3), pp. e0339600. Date of Electronic Publication: 2026 Mar 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early administration of renin-angiotensin system inhibitors improves survival and cardiac remodeling in heart failure with preserved ejection fraction.
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  Data: <searchLink fieldCode="AU" term="%22Kono+Y%22">Kono Y</searchLink>; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan.; Collage of Human Life and Environment, Kinjo Gakuin University, Nagoya-shi, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Sonoda+K%22">Sonoda K</searchLink>; Collage of Human Life and Environment, Kinjo Gakuin University, Nagoya-shi, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Ohtake+K%22">Ohtake K</searchLink>; School of Pharmacy, Faculty of Pharmaceutical Science, Josai University, Sakado-shi, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Ota+A%22">Ota A</searchLink>; Collage of Human Life and Environment, Kinjo Gakuin University, Nagoya-shi, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+S%22">Yamamoto S</searchLink>; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan.; Academic Field of Health Science, Okayama University, Okayama-shi, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Nakayama+H%22">Nakayama H</searchLink>; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuoka+T%22">Fukuoka T</searchLink>; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Kawai+Y%22">Kawai Y</searchLink>; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Tago+H%22">Tago H</searchLink>; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+N%22">Watanabe N</searchLink>; Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama-shi, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+I%22">Sato I</searchLink>; Academic Field of Health Science, Okayama University, Okayama-shi, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Hirohata+S%22">Hirohata S</searchLink>; Academic Field of Health Science, Okayama University, Okayama-shi, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Kitamori+K%22">Kitamori K</searchLink>; Collage of Human Life and Environment, Kinjo Gakuin University, Nagoya-shi, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+S%22">Watanabe S</searchLink>; Academic Field of Health Science, Okayama University, Okayama-shi, Okayama, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Mar 12; Vol. 21 (3), pp. e0339600. <i>Date of Electronic Publication: </i>2026 Mar 12 (<i>Print Publication: </i>2026).
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