The angiotensin II receptor blocker candesartan mitigates cisplatin-induced myocardial injury via suppression of TLR-4/NF-κB/IRF-3/AP-1 signaling and restoration of antioxidant defenses.
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| Title: | The angiotensin II receptor blocker candesartan mitigates cisplatin-induced myocardial injury via suppression of TLR-4/NF-κB/IRF-3/AP-1 signaling and restoration of antioxidant defenses. |
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| Authors: | Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt., Abd El-Ghafar OAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef 62521, Egypt., Alnasser SM; Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 52571, Saudi Arabia., Alruhaimi RS; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Althagafy HS; Division of Biochemistry, Department of Biological Sciences, Faculty of Science, University of Jeddah, Jeddah 21589, Saudi Arabia., Atwa AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo 11829, Egypt., Mahmoud AM; Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester M1 5GD, UK; Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: a.mahmoud@mmu.ac.uk. |
| Source: | Tissue & cell [Tissue Cell] 2026 Aug; Vol. 101, pp. 103452. Date of Electronic Publication: 2026 Mar 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41819042 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The angiotensin II receptor blocker candesartan mitigates cisplatin-induced myocardial injury via suppression of TLR-4/NF-κB/IRF-3/AP-1 signaling and restoration of antioxidant defenses. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hassanein+EHM%22">Hassanein EHM</searchLink>; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.<br /><searchLink fieldCode="AU" term="%22Abd+El-Ghafar+OAM%22">Abd El-Ghafar OAM</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef 62521, Egypt.<br /><searchLink fieldCode="AU" term="%22Alnasser+SM%22">Alnasser SM</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 52571, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alruhaimi+RS%22">Alruhaimi RS</searchLink>; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Althagafy+HS%22">Althagafy HS</searchLink>; Division of Biochemistry, Department of Biological Sciences, Faculty of Science, University of Jeddah, Jeddah 21589, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Atwa+AM%22">Atwa AM</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo 11829, Egypt.<br /><searchLink fieldCode="AU" term="%22Mahmoud+AM%22">Mahmoud AM</searchLink>; Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester M1 5GD, UK; Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: a.mahmoud@mmu.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220214745%22">Tissue & cell</searchLink> [Tissue Cell] 2026 Aug; Vol. 101, pp. 103452. <i>Date of Electronic Publication: </i>2026 Mar 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Churchill+Livingstone%22">Churchill Livingstone </searchLink><i>Country of Publication: </i>Scotland <i>NLM ID: </i>0214745 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-3072 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200408166%22">00408166 </searchLink><i>NLM ISO Abbreviation: </i>Tissue Cell <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41819042 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.tice.2026.103452 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 103452 Titles: – TitleFull: The angiotensin II receptor blocker candesartan mitigates cisplatin-induced myocardial injury via suppression of TLR-4/NF-κB/IRF-3/AP-1 signaling and restoration of antioxidant defenses. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hassanein EHM – PersonEntity: Name: NameFull: Abd El-Ghafar OAM – PersonEntity: Name: NameFull: Alnasser SM – PersonEntity: Name: NameFull: Alruhaimi RS – PersonEntity: Name: NameFull: Althagafy HS – PersonEntity: Name: NameFull: Atwa AM – PersonEntity: Name: NameFull: Mahmoud AM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2026 Aug Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1532-3072 Numbering: – Type: volume Value: 101 Titles: – TitleFull: Tissue & cell Type: main |
| ResultId | 1 |
