The angiotensin II receptor blocker candesartan mitigates cisplatin-induced myocardial injury via suppression of TLR-4/NF-κB/IRF-3/AP-1 signaling and restoration of antioxidant defenses.
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| Title: | The angiotensin II receptor blocker candesartan mitigates cisplatin-induced myocardial injury via suppression of TLR-4/NF-κB/IRF-3/AP-1 signaling and restoration of antioxidant defenses. |
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| Authors: | Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt., Abd El-Ghafar OAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef 62521, Egypt., Alnasser SM; Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 52571, Saudi Arabia., Alruhaimi RS; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Althagafy HS; Division of Biochemistry, Department of Biological Sciences, Faculty of Science, University of Jeddah, Jeddah 21589, Saudi Arabia., Atwa AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo 11829, Egypt., Mahmoud AM; Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester M1 5GD, UK; Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: a.mahmoud@mmu.ac.uk. |
| Source: | Tissue & cell [Tissue Cell] 2026 Aug; Vol. 101, pp. 103452. Date of Electronic Publication: 2026 Mar 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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