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Impact of high relative dose intensity on effectiveness and treatment continuity of IO-TKI therapy in Japanese advanced renal cell carcinoma.

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Title: Impact of high relative dose intensity on effectiveness and treatment continuity of IO-TKI therapy in Japanese advanced renal cell carcinoma.
Authors: Tasaki Y; Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Hamamoto S; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan. hamamo10@med.nagoya-cu.ac.jp., Ikoma H; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Tomita M; Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Sakata T; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Suzuki H; Department of Urology, Kainan Hospital, 396 Minamihonda, Maegasu-Cho, Yatomi, Aichi, 498-8502, Japan., Noda Y; Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-Cho, Anjo, Aichi, 467-8601, Japan., Usami M; Department of Urology, Toyota Kosei Hospital, 1-500 Ibobara, Josui-Cho, Toyota, Aichi, 470-0396, Japan., Tsubouchi Y; Department of Urology, Konan Kosei Hospital, 137 Omatsubara, Takaya-Cho, Konan, Aichi, 483-8704, Japan., Morikawa T; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Mimura Y; Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Sugiyama Y; Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Nagai T; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Unno R; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Etani T; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Naiki T; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Furukawa-Hibi Y; Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan., Yasui T; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.
Source: Scientific reports [Sci Rep] 2026 Mar 12; Vol. 16 (1). Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process
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  Data: <searchLink fieldCode="AU" term="%22Tasaki+Y%22">Tasaki Y</searchLink>; Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Hamamoto+S%22">Hamamoto S</searchLink>; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan. hamamo10@med.nagoya-cu.ac.jp.<br /><searchLink fieldCode="AU" term="%22Ikoma+H%22">Ikoma H</searchLink>; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Tomita+M%22">Tomita M</searchLink>; Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Sakata+T%22">Sakata T</searchLink>; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+H%22">Suzuki H</searchLink>; Department of Urology, Kainan Hospital, 396 Minamihonda, Maegasu-Cho, Yatomi, Aichi, 498-8502, Japan.<br /><searchLink fieldCode="AU" term="%22Noda+Y%22">Noda Y</searchLink>; Department of Urology, Anjo Kosei Hospital, 28 Higashihirokute, Anjo-Cho, Anjo, Aichi, 467-8601, Japan.<br /><searchLink fieldCode="AU" term="%22Usami+M%22">Usami M</searchLink>; Department of Urology, Toyota Kosei Hospital, 1-500 Ibobara, Josui-Cho, Toyota, Aichi, 470-0396, Japan.<br /><searchLink fieldCode="AU" term="%22Tsubouchi+Y%22">Tsubouchi Y</searchLink>; Department of Urology, Konan Kosei Hospital, 137 Omatsubara, Takaya-Cho, Konan, Aichi, 483-8704, Japan.<br /><searchLink fieldCode="AU" term="%22Morikawa+T%22">Morikawa T</searchLink>; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Mimura+Y%22">Mimura Y</searchLink>; Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Sugiyama+Y%22">Sugiyama Y</searchLink>; Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Nagai+T%22">Nagai T</searchLink>; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Unno+R%22">Unno R</searchLink>; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Etani+T%22">Etani T</searchLink>; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Naiki+T%22">Naiki T</searchLink>; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Furukawa-Hibi+Y%22">Furukawa-Hibi Y</searchLink>; Department of Clinical Pharmaceutics, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Yasui+T%22">Yasui T</searchLink>; Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi, Japan.
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