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Oncolytic adenovirus encoding a TGF-β inhibitor synergizes with PD-1 blockade to potentiate NK cell cytotoxicity against NSCLC.

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Title: Oncolytic adenovirus encoding a TGF-β inhibitor synergizes with PD-1 blockade to potentiate NK cell cytotoxicity against NSCLC.
Authors: Zhu Z; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China., Xu C; Beijing Anzhen Hospital, Capital Medical University, Beijing, China.; School of Basic Medical Sciences, Capital Medical University, Beijing, China., Kong X; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China., Zhang S; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China., Lu S; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China., Zhang S; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China., Xu W; Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China., Zhang Q; Department of Anesthesiology, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China., Zhu M; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China.
Source: Frontiers in immunology [Front Immunol] 2026 Feb 25; Vol. 17, pp. 1759236. Date of Electronic Publication: 2026 Feb 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oncolytic adenovirus encoding a TGF-β inhibitor synergizes with PD-1 blockade to potentiate NK cell cytotoxicity against NSCLC.
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  Data: <searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Beijing Anzhen Hospital, Capital Medical University, Beijing, China.; School of Basic Medical Sciences, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Kong+X%22">Kong X</searchLink>; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Lu+S%22">Lu S</searchLink>; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink>; Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Anesthesiology, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhu+M%22">Zhu M</searchLink>; Department of Clinical Laboratory, The Fourth Affiliated Hospital (Affiliated Chaohu Hospital) of Anhui Medical University, Chaohu, Anhui, China.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Feb 25; Vol. 17, pp. 1759236. <i>Date of Electronic Publication: </i>2026 Feb 25 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.3389/fimmu.2026.1759236
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        Text: English
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              Text: 2026 Feb 25
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