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Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders.

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Title: Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders.
Authors: Kumar A; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA., Ray NR; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA., Kurup JT; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA., Rosario PD; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA., Manoochehri M; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA., Stein C; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA., De Vito AN; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA., Cholerton B; Department of Pathology, Stanford University, Stanford, California, USA., Sweet RA; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., de Jager PL; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Klein HU; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Cuccaro ML; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. MacDonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA., Beecham GW; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Huey ED; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA., Reitz C; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA.; Department of Epidemiology, Columbia University, New York, New York, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Mar; Vol. 22 (3), pp. e71278.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders.
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  Data: <searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Ray+NR%22">Ray NR</searchLink>; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Kurup+JT%22">Kurup JT</searchLink>; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Rosario+PD%22">Rosario PD</searchLink>; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Manoochehri+M%22">Manoochehri M</searchLink>; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Stein+C%22">Stein C</searchLink>; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22De+Vito+AN%22">De Vito AN</searchLink>; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Cholerton+B%22">Cholerton B</searchLink>; Department of Pathology, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Sweet+RA%22">Sweet RA</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22de+Jager+PL%22">de Jager PL</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Klein+HU%22">Klein HU</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Cuccaro+ML%22">Cuccaro ML</searchLink>; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. MacDonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Beecham+GW%22">Beecham GW</searchLink>; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Huey+ED%22">Huey ED</searchLink>; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Reitz+C%22">Reitz C</searchLink>; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA.; Department of Epidemiology, Columbia University, New York, New York, USA.
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        Value: 10.1002/alz.71278
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      – TitleFull: Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders.
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              Text: 2026 Mar
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