A phase 1 study of berzosertib (M6620, VX-970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950).
Saved in:
| Title: | A phase 1 study of berzosertib (M6620, VX-970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950). |
|---|---|
| Authors: | Bhatia A; Yale School of Medicine and Yale Cancer Center, New Haven, Connecticut, USA., Chen Z; Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois, USA., Zhang Y; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Bruce JY; Division of Hematology, Medical Oncology, and Palliative Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Arnold S; Markey Cancer Center, Lexington, Kentucky, USA., Kaur V; University of Virginia, Charlottesville, Virginia, USA., Riess JW; Division of Hematology/Oncology, UC Davis Comprehensive Cancer Center, Davis, California, USA., Fenton M; Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Burtness B; Yale School of Medicine and Yale Cancer Center, New Haven, Connecticut, USA., Saba NF; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Tara H; Yale School of Medicine and Yale Cancer Center, New Haven, Connecticut, USA., Steuer CE; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Shin DM; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA., Wasp G; Dartmouth Cancer Center, Lebanon, New Hampshire, USA., Davis TH; Dartmouth Cancer Center, Lebanon, New Hampshire, USA., Patel M; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA., Schmitz JC; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA., Bhateja P; Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA., Diavolitsis V; Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA., Zandberg DP; Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Mitchell DL; Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA., Kiesel BF; Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA., Kunos C; Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA., Gore SD; Division of Cancer Treatment and Diagnosis, Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA., Carducci M; Department of Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, USA., Beumer JH; Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.; Department of Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, USA., Owonikoko TK; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA. |
| Source: | Cancer [Cancer] 2026 Mar 15; Vol. 132 (6), pp. e70346. |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 0374236 Publication Model: Print Cited Medium: Internet ISSN: 1097-0142 (Electronic) Linking ISSN: 0008543X NLM ISO Abbreviation: Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41823504 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: A phase 1 study of berzosertib (M6620, VX-970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bhatia+A%22">Bhatia A</searchLink>; Yale School of Medicine and Yale Cancer Center, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Bruce+JY%22">Bruce JY</searchLink>; Division of Hematology, Medical Oncology, and Palliative Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Arnold+S%22">Arnold S</searchLink>; Markey Cancer Center, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Kaur+V%22">Kaur V</searchLink>; University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Riess+JW%22">Riess JW</searchLink>; Division of Hematology/Oncology, UC Davis Comprehensive Cancer Center, Davis, California, USA.<br /><searchLink fieldCode="AU" term="%22Fenton+M%22">Fenton M</searchLink>; Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Burtness+B%22">Burtness B</searchLink>; Yale School of Medicine and Yale Cancer Center, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Saba+NF%22">Saba NF</searchLink>; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Tara+H%22">Tara H</searchLink>; Yale School of Medicine and Yale Cancer Center, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Steuer+CE%22">Steuer CE</searchLink>; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Shin+DM%22">Shin DM</searchLink>; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Wasp+G%22">Wasp G</searchLink>; Dartmouth Cancer Center, Lebanon, New Hampshire, USA.<br /><searchLink fieldCode="AU" term="%22Davis+TH%22">Davis TH</searchLink>; Dartmouth Cancer Center, Lebanon, New Hampshire, USA.<br /><searchLink fieldCode="AU" term="%22Patel+M%22">Patel M</searchLink>; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Schmitz+JC%22">Schmitz JC</searchLink>; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Bhateja+P%22">Bhateja P</searchLink>; Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Diavolitsis+V%22">Diavolitsis V</searchLink>; Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Zandberg+DP%22">Zandberg DP</searchLink>; Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+DL%22">Mitchell DL</searchLink>; Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Kiesel+BF%22">Kiesel BF</searchLink>; Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Kunos+C%22">Kunos C</searchLink>; Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Gore+SD%22">Gore SD</searchLink>; Division of Cancer Treatment and Diagnosis, Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Carducci+M%22">Carducci M</searchLink>; Department of Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Beumer+JH%22">Beumer JH</searchLink>; Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.; Department of Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Owonikoko+TK%22">Owonikoko TK</searchLink>; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220374236%22">Cancer</searchLink> [Cancer] 2026 Mar 15; Vol. 132 (6), pp. e70346. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0374236 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-0142 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220008543X%22">0008543X </searchLink><i>NLM ISO Abbreviation: </i>Cancer <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41823504 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/cncr.70346 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e70346 Titles: – TitleFull: A phase 1 study of berzosertib (M6620, VX-970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bhatia A – PersonEntity: Name: NameFull: Chen Z – PersonEntity: Name: NameFull: Zhang Y – PersonEntity: Name: NameFull: Bruce JY – PersonEntity: Name: NameFull: Arnold S – PersonEntity: Name: NameFull: Kaur V – PersonEntity: Name: NameFull: Riess JW – PersonEntity: Name: NameFull: Fenton M – PersonEntity: Name: NameFull: Burtness B – PersonEntity: Name: NameFull: Saba NF – PersonEntity: Name: NameFull: Tara H – PersonEntity: Name: NameFull: Steuer CE – PersonEntity: Name: NameFull: Shin DM – PersonEntity: Name: NameFull: Wasp G – PersonEntity: Name: NameFull: Davis TH – PersonEntity: Name: NameFull: Patel M – PersonEntity: Name: NameFull: Schmitz JC – PersonEntity: Name: NameFull: Bhateja P – PersonEntity: Name: NameFull: Diavolitsis V – PersonEntity: Name: NameFull: Zandberg DP – PersonEntity: Name: NameFull: Mitchell DL – PersonEntity: Name: NameFull: Kiesel BF – PersonEntity: Name: NameFull: Kunos C – PersonEntity: Name: NameFull: Gore SD – PersonEntity: Name: NameFull: Carducci M – PersonEntity: Name: NameFull: Beumer JH – PersonEntity: Name: NameFull: Owonikoko TK IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 03 Text: 2026 Mar 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1097-0142 Numbering: – Type: volume Value: 132 – Type: issue Value: 6 Titles: – TitleFull: Cancer Type: main |
| ResultId | 1 |
