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PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury.

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Title: PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury.
Authors: Li Y; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China., Wang Y; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhang H; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Xu P; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Yuan X; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Yuan H; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Yang C; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhou Y; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Shen J; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Du H; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Gao Z; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China., Zang J; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China., Liang S; Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. simondoctor@163.com., Qu J; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. qujing@ioz.ac.cn.; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. qujing@ioz.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. qujing@ioz.ac.cn., Song M; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. songmoshi@ioz.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. songmoshi@ioz.ac.cn.
Source: Basic research in cardiology [Basic Res Cardiol] 2026 Jun; Vol. 121 (3), pp. 395-412. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Steinkopff Country of Publication: Germany NLM ID: 0360342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1803 (Electronic) Linking ISSN: 03008428 NLM ISO Abbreviation: Basic Res Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury.
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  Data: <searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Xu+P%22">Xu P</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Yuan+X%22">Yuan X</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Yuan+H%22">Yuan H</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Shen+J%22">Shen J</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Du+H%22">Du H</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Gao+Z%22">Gao Z</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.<br /><searchLink fieldCode="AU" term="%22Zang+J%22">Zang J</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.<br /><searchLink fieldCode="AU" term="%22Liang+S%22">Liang S</searchLink>; Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. simondoctor@163.com.<br /><searchLink fieldCode="AU" term="%22Qu+J%22">Qu J</searchLink>; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. qujing@ioz.ac.cn.; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. qujing@ioz.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. qujing@ioz.ac.cn.<br /><searchLink fieldCode="AU" term="%22Song+M%22">Song M</searchLink>; State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. songmoshi@ioz.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. songmoshi@ioz.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%220360342%22">Basic research in cardiology</searchLink> [Basic Res Cardiol] 2026 Jun; Vol. 121 (3), pp. 395-412. <i>Date of Electronic Publication: </i>2026 Mar 13.
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        Value: 10.1007/s00395-026-01169-6
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        Text: English
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      – TitleFull: PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury.
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              Text: 2026 Jun
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              Y: 2026
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