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Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides.

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Title: Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides.
Authors: Uchiyama J; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan; Department of Adduct Biology and Gut Microbial Function, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Shimizu Y; Department of Biochemistry, Showa Medical University School of Medicine, Tokyo, Japan., Unoki T; Department of Health Chemistry, Showa Pharmaceutical University, Tokyo, Japan., Kasamatsu S; Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka, Japan., Ida T; Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka, Japan., Ihara H; Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka, Japan., Kim YG; Department of Microbiology, School of Pharmacy, Kitasato University, Tokyo, Japan., Hase K; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan., Miura Y; Research Team for Mechanism of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Maehama T; Department of Biochemistry, Showa Medical University School of Medicine, Tokyo, Japan., Kusano M; Department of Legal Medicine, Showa Medical University School of Medicine, Tokyo, Japan., Umezawa K; Research Team for Mechanism of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan. Electronic address: umezawa@tmig.or.jp., Akiyama M; Department of Adduct Biology and Gut Microbial Function, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan. Electronic address: akiyama.sw@med.showa-u.ac.jp.
Source: Redox biology [Redox Biol] 2026 May; Vol. 92, pp. 104123. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
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  Data: Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides.
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  Data: <searchLink fieldCode="AU" term="%22Uchiyama+J%22">Uchiyama J</searchLink>; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan; Department of Adduct Biology and Gut Microbial Function, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+Y%22">Shimizu Y</searchLink>; Department of Biochemistry, Showa Medical University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Unoki+T%22">Unoki T</searchLink>; Department of Health Chemistry, Showa Pharmaceutical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kasamatsu+S%22">Kasamatsu S</searchLink>; Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ida+T%22">Ida T</searchLink>; Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ihara+H%22">Ihara H</searchLink>; Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kim+YG%22">Kim YG</searchLink>; Department of Microbiology, School of Pharmacy, Kitasato University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hase+K%22">Hase K</searchLink>; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Miura+Y%22">Miura Y</searchLink>; Research Team for Mechanism of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Maehama+T%22">Maehama T</searchLink>; Department of Biochemistry, Showa Medical University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kusano+M%22">Kusano M</searchLink>; Department of Legal Medicine, Showa Medical University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Umezawa+K%22">Umezawa K</searchLink>; Research Team for Mechanism of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan. Electronic address: umezawa@tmig.or.jp.<br /><searchLink fieldCode="AU" term="%22Akiyama+M%22">Akiyama M</searchLink>; Department of Adduct Biology and Gut Microbial Function, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan. Electronic address: akiyama.sw@med.showa-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101605639%22">Redox biology</searchLink> [Redox Biol] 2026 May; Vol. 92, pp. 104123. <i>Date of Electronic Publication: </i>2026 Mar 11.
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