View in EDS HTML Full Text PDF Full Text

Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis: The PARADIGM Randomized Clinical Trial.

Saved in:
Bibliographic Details
Title: Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis: The PARADIGM Randomized Clinical Trial.
Authors: Cudkowicz M; Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Drory VE; Department of Neurology, Tel-Aviv Sourasky Medical Centre, Tel Aviv, Israel.; Gray Faculty of Medical and Health Science, Tel Aviv University, Tel Aviv, Israel., Chio A; Rita Levi Montalcini Department of Neuroscience, University of Torino and Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Lunetta C; Istituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Department, Milan, Italy., Shoesmith C; Department of Clinical Neurological Sciences, Division of Neurology, London Health Sciences Centre, London, Ontario, Canada., van Eijk RPA; Department of Neurology and Biostatistics, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Salomon-Zimri S; NeuroSense Therapeutics, Herzliya, Israel., Shtossel D; NeuroSense Therapeutics, Herzliya, Israel., Kerem N; NeuroSense Therapeutics, Herzliya, Israel., Shapira G; Gray Faculty of Medical and Health Science, Tel Aviv University, Tel Aviv, Israel., Shomron N; Gray Faculty of Medical and Health Science, Tel Aviv University, Tel Aviv, Israel., Russek-Blum N; NeuroSense Therapeutics, Herzliya, Israel., Tracik F; NeuroSense Therapeutics, Ulm, Germany., Rosenfeld J; Department of Neurology, Loma Linda University School of Medicine, Loma Linda, California., Shefner J; Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona.
Source: JAMA neurology [JAMA Neurol] 2026 May 01; Vol. 83 (5), pp. 471-480.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41837970
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis: The PARADIGM Randomized Clinical Trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Cudkowicz+M%22">Cudkowicz M</searchLink>; Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Drory+VE%22">Drory VE</searchLink>; Department of Neurology, Tel-Aviv Sourasky Medical Centre, Tel Aviv, Israel.; Gray Faculty of Medical and Health Science, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Chio+A%22">Chio A</searchLink>; Rita Levi Montalcini Department of Neuroscience, University of Torino and Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Lunetta+C%22">Lunetta C</searchLink>; Istituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Department, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Shoesmith+C%22">Shoesmith C</searchLink>; Department of Clinical Neurological Sciences, Division of Neurology, London Health Sciences Centre, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22van+Eijk+RPA%22">van Eijk RPA</searchLink>; Department of Neurology and Biostatistics, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Salomon-Zimri+S%22">Salomon-Zimri S</searchLink>; NeuroSense Therapeutics, Herzliya, Israel.<br /><searchLink fieldCode="AU" term="%22Shtossel+D%22">Shtossel D</searchLink>; NeuroSense Therapeutics, Herzliya, Israel.<br /><searchLink fieldCode="AU" term="%22Kerem+N%22">Kerem N</searchLink>; NeuroSense Therapeutics, Herzliya, Israel.<br /><searchLink fieldCode="AU" term="%22Shapira+G%22">Shapira G</searchLink>; Gray Faculty of Medical and Health Science, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Shomron+N%22">Shomron N</searchLink>; Gray Faculty of Medical and Health Science, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Russek-Blum+N%22">Russek-Blum N</searchLink>; NeuroSense Therapeutics, Herzliya, Israel.<br /><searchLink fieldCode="AU" term="%22Tracik+F%22">Tracik F</searchLink>; NeuroSense Therapeutics, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Rosenfeld+J%22">Rosenfeld J</searchLink>; Department of Neurology, Loma Linda University School of Medicine, Loma Linda, California.<br /><searchLink fieldCode="AU" term="%22Shefner+J%22">Shefner J</searchLink>; Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101589536%22">JAMA neurology</searchLink> [JAMA Neurol] 2026 May 01; Vol. 83 (5), pp. 471-480.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101589536 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2168-6157 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221686149%22">21686149 </searchLink><i>NLM ISO Abbreviation: </i>JAMA Neurol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41837970
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1001/jamaneurol.2026.0230
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 471
    Titles:
      – TitleFull: Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis: The PARADIGM Randomized Clinical Trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Cudkowicz M
      – PersonEntity:
          Name:
            NameFull: Drory VE
      – PersonEntity:
          Name:
            NameFull: Chio A
      – PersonEntity:
          Name:
            NameFull: Lunetta C
      – PersonEntity:
          Name:
            NameFull: Shoesmith C
      – PersonEntity:
          Name:
            NameFull: van Eijk RPA
      – PersonEntity:
          Name:
            NameFull: Salomon-Zimri S
      – PersonEntity:
          Name:
            NameFull: Shtossel D
      – PersonEntity:
          Name:
            NameFull: Kerem N
      – PersonEntity:
          Name:
            NameFull: Shapira G
      – PersonEntity:
          Name:
            NameFull: Shomron N
      – PersonEntity:
          Name:
            NameFull: Russek-Blum N
      – PersonEntity:
          Name:
            NameFull: Tracik F
      – PersonEntity:
          Name:
            NameFull: Rosenfeld J
      – PersonEntity:
          Name:
            NameFull: Shefner J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2026 May 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2168-6157
          Numbering:
            – Type: volume
              Value: 83
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: JAMA neurology
              Type: main
ResultId 1