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Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity.

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Title: Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity.
Authors: Bivins MM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., Tomberg J; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., Bagshaw M; Department of Biology, University of North Carolina - Chapel Hill, Chapel Hill, North Carolina, United States of America., Singh A; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America., Bala S; Department of Biochemistry & Molecular Biology, University of South Alabama, Mobile, Alabama, United States of America., Davies C; Department of Biochemistry & Molecular Biology, University of South Alabama, Mobile, Alabama, United States of America., Nicholas RA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Source: PLoS pathogens [PLoS Pathog] 2026 Mar 17; Vol. 22 (3), pp. e1013721. Date of Electronic Publication: 2026 Mar 17 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity.
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  Data: <searchLink fieldCode="AU" term="%22Bivins+MM%22">Bivins MM</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Tomberg+J%22">Tomberg J</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Bagshaw+M%22">Bagshaw M</searchLink>; Department of Biology, University of North Carolina - Chapel Hill, Chapel Hill, North Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Singh+A%22">Singh A</searchLink>; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America.<br /><searchLink fieldCode="AU" term="%22Bala+S%22">Bala S</searchLink>; Department of Biochemistry & Molecular Biology, University of South Alabama, Mobile, Alabama, United States of America.<br /><searchLink fieldCode="AU" term="%22Davies+C%22">Davies C</searchLink>; Department of Biochemistry & Molecular Biology, University of South Alabama, Mobile, Alabama, United States of America.<br /><searchLink fieldCode="AU" term="%22Nicholas+RA%22">Nicholas RA</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
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  Data: <searchLink fieldCode="JN" term="%22101238921%22">PLoS pathogens</searchLink> [PLoS Pathog] 2026 Mar 17; Vol. 22 (3), pp. e1013721. <i>Date of Electronic Publication: </i>2026 Mar 17 (<i>Print Publication: </i>2026).
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      – TitleFull: Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity.
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