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The Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCC.

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Title: The Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCC.
Authors: Kuroda S; Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan., Funasaki S; Divison of Molecular and Vascular Biology, IRDA, Kumamoto University, Kumamoto 860-0811, Japan., Nishizawa H; Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan., Schmidt LS; Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Kurahashi R; Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan., Ito T; Department of Medical Technology, Faculty of Health Sciences, Kumamoto Health Science University, Kumamoto 861-5598, Japan., Arima Y; Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan., Tanaka M; Project for Cancer Epigenomics, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan., Kitada A; Department of Micro Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8540, Japan., James AM; Animal research Technical Support, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Hasumi H; Department of Urology, Yokohama City University Graduate School of Medicine, Kanagawa 236-0004, Japan., Jikuya R; Department of Urology, Yokohama City University Graduate School of Medicine, Kanagawa 236-0004, Japan., Makiyama K; Department of Urology, Yokohama City University Graduate School of Medicine, Kanagawa 236-0004, Japan., Kurotaki D; Laboratory of Chromatin Organization in Immune Cell Development, International Research Center for Medical Sciences, Kumamoto University, Kumamoto 860-0811, Japan., Minami T; Divison of Molecular and Vascular Biology, IRDA, Kumamoto University, Kumamoto 860-0811, Japan., Difilippantonio S; Animal research Technical Support, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Linehan WM; Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Oike Y; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan., Sawa T; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan., Tanaka Y; Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan., Suda T; State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Tianjin, China., Yokokawa R; Department of Micro Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8540, Japan., Nakamura T; Department of Experimental Pathology, Institute of Medical Science, Tokyo Medical University, Tokyo 160-8402, Japan., Baba M; Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan. Electronic address: babam@kumamoto-u.ac.jp., Kamba T; Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Source: Neoplasia (New York, N.Y.) [Neoplasia] 2026 May; Vol. 75, pp. 101296. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE
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