M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation.
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| Title: | M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation. |
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| Authors: | Zhang MY; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China. zhangmingyu.302@163.com.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China. zhangmingyu.302@163.com., Ji DN; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Qi WY; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Wang S; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Dai CY; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Xu FY; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Dong Z; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Xiong C; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Zhang BW; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Institute of Clinical Pharmacy, the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, PR China., Wang Y; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Guo XF; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Institute of Clinical Pharmacy, the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, PR China., Zhang B; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Cheng WZ; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Zhang XY; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Jin SD; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Guan XX; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Institute of Clinical Pharmacy, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, PR China., Hong H; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Zhou T; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Li SF; Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, PR China., Zhang R; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Sun LH; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Xuan LN; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China., Jiang Y; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China. yuanjiang@hrbmu.edu.cn.; Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China. yuanjiang@hrbmu.edu.cn., Yang BF; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China. yangbf@ems.hrbmu.edu.cn.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China. yangbf@ems.hrbmu.edu.cn., Xu CQ; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory -Province Key Laboratories of Biomedicine--Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China. xuchaoqian@ems.hrbmu.edu.cn.; Joint International Research Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin, Heilongjiang, PR China. xuchaoqian@ems.hrbmu.edu.cn. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Mar 17; Vol. 11 (1). Date of Electronic Publication: 2026 Mar 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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