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A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.

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Title: A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.
Authors: Chen X; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.; Department of Physiology, University of California San Francisco, San Francisco, CA 94158.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94158., Zhong X; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.; Department of Physiology, University of California San Francisco, San Francisco, CA 94158.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94158., Yue W; Department of Medicine and Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143., Wang B; Department of Medicine and Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143., Woo B; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158., Goodarzi H; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158., Luo Z; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294., Lu QR; Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229., Flamant F; Ecole Normale Supérieure de Lyon, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), CNRS, Institut de Génomique Fonctionnelle de Lyon, Lyon 69007, France., Reiter JF; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158.; Chan Zuckerberg Biohub, San Francisco, CA 94158., Huang GN; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.; Department of Physiology, University of California San Francisco, San Francisco, CA 94158.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94158.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 24; Vol. 123 (12), pp. e2527163123. Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.
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  Data: <searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.; Department of Physiology, University of California San Francisco, San Francisco, CA 94158.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94158.<br /><searchLink fieldCode="AU" term="%22Zhong+X%22">Zhong X</searchLink>; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.; Department of Physiology, University of California San Francisco, San Francisco, CA 94158.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94158.<br /><searchLink fieldCode="AU" term="%22Yue+W%22">Yue W</searchLink>; Department of Medicine and Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Department of Medicine and Division of Gastroenterology, University of California San Francisco, San Francisco, CA 94143.<br /><searchLink fieldCode="AU" term="%22Woo+B%22">Woo B</searchLink>; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158.<br /><searchLink fieldCode="AU" term="%22Goodarzi+H%22">Goodarzi H</searchLink>; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158.<br /><searchLink fieldCode="AU" term="%22Luo+Z%22">Luo Z</searchLink>; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294.<br /><searchLink fieldCode="AU" term="%22Lu+QR%22">Lu QR</searchLink>; Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.<br /><searchLink fieldCode="AU" term="%22Flamant+F%22">Flamant F</searchLink>; Ecole Normale Supérieure de Lyon, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), CNRS, Institut de Génomique Fonctionnelle de Lyon, Lyon 69007, France.<br /><searchLink fieldCode="AU" term="%22Reiter+JF%22">Reiter JF</searchLink>; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158.; Chan Zuckerberg Biohub, San Francisco, CA 94158.<br /><searchLink fieldCode="AU" term="%22Huang+GN%22">Huang GN</searchLink>; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158.; Department of Physiology, University of California San Francisco, San Francisco, CA 94158.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94158.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Mar 24; Vol. 123 (12), pp. e2527163123. <i>Date of Electronic Publication: </i>2026 Mar 18.
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