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Identification of a Druggable Target That Predicts Postoperative Crohn's Disease Recurrence.

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Title: Identification of a Druggable Target That Predicts Postoperative Crohn's Disease Recurrence.
Authors: Verstockt S; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium., Schwärzler J; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria., Willeit P; Institute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Vienna, Austria; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Bislenghi G; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium; Department of Abdominal Surgery, University Hospitals Leuven, Leuven, Belgium., Meyer M; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria., Mayr L; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria., Machiels K; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium., De Hertogh G; Department of Pathology, University Hospitals Leuven, Leuven, Belgium., Lenfant M; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium., Scheffauer L; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria., Grabherr F; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria., Jans DS; Laboratory for Complex Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Abdurahiman S; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium., Cleynen I; Laboratory for Complex Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Jukic A; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria., Zundel L; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria., Moser P; INNPATH, Innsbruck Medical University Hospital, Innsbruck, Austria., Forer L; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria., Witsch-Baumgartner M; Institute of Human Genetics, Medical University Innsbruck, Innsbruck, Austria., Ferrante M; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium., Sabino J; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium., D'Hoore A; Department of Abdominal Surgery, University Hospitals Leuven, Leuven, Belgium., Hess M; Institute of Histology & Embryology, Medical University of Innsbruck, Innsbruck, Austria., Kaser A; Division of Gastroenterology and Hepatology, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom., Blumberg RS; Gastroenterology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Koch R; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria., Le Bourhis L; Université de Paris cité, INSERM U1342, Institut de Recherche Saint-Louis, Paris, France., Hammoudi N; Université de Paris cité, INSERM U1342, Institut de Recherche Saint-Louis, Paris, France; Gastroenterology Department, Hôpital Saint-Louis, Assistance Publique -Hôpitaux de Paris, Paris, France., Cazals-Hatem D; Pathology Department, Hôpital Beaujon, Assistance Publique -Hôpitaux de Paris, Clichy, France., Vermeire S; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium., Tilg H; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria., Allez M; Université de Paris cité, INSERM U1342, Institut de Recherche Saint-Louis, Paris, France; Gastroenterology Department, Hôpital Saint-Louis, Assistance Publique -Hôpitaux de Paris, Paris, France., Verstockt B; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium. Electronic address: bram.verstockt@uzleuven.be., Adolph TE; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: timon-erik.adolph@i-med.ac.at.
Source: Gastroenterology [Gastroenterology] 2026 Mar 16. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
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Department of Abdominal Surgery, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Meyer+M%22">Meyer M</searchLink>; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Mayr+L%22">Mayr L</searchLink>; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Machiels+K%22">Machiels K</searchLink>; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Hertogh+G%22">De Hertogh G</searchLink>; Department of Pathology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Lenfant+M%22">Lenfant M</searchLink>; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Scheffauer+L%22">Scheffauer L</searchLink>; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Grabherr+F%22">Grabherr F</searchLink>; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Jans+DS%22">Jans DS</searchLink>; Laboratory for Complex Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Abdurahiman+S%22">Abdurahiman S</searchLink>; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Cleynen+I%22">Cleynen I</searchLink>; Laboratory for Complex Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Jukic+A%22">Jukic A</searchLink>; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Zundel+L%22">Zundel L</searchLink>; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Moser+P%22">Moser P</searchLink>; INNPATH, Innsbruck Medical University Hospital, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Forer+L%22">Forer L</searchLink>; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Witsch-Baumgartner+M%22">Witsch-Baumgartner M</searchLink>; Institute of Human Genetics, Medical University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Ferrante+M%22">Ferrante M</searchLink>; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sabino+J%22">Sabino J</searchLink>; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22D'Hoore+A%22">D'Hoore A</searchLink>; Department of Abdominal Surgery, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Hess+M%22">Hess M</searchLink>; Institute of Histology & Embryology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Kaser+A%22">Kaser A</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Blumberg+RS%22">Blumberg RS</searchLink>; Gastroenterology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Koch+R%22">Koch R</searchLink>; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Le+Bourhis+L%22">Le Bourhis L</searchLink>; Université de Paris cité, INSERM U1342, Institut de Recherche Saint-Louis, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hammoudi+N%22">Hammoudi N</searchLink>; Université de Paris cité, INSERM U1342, Institut de Recherche Saint-Louis, Paris, France; Gastroenterology Department, Hôpital Saint-Louis, Assistance Publique -Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cazals-Hatem+D%22">Cazals-Hatem D</searchLink>; Pathology Department, Hôpital Beaujon, Assistance Publique -Hôpitaux de Paris, Clichy, France.<br /><searchLink fieldCode="AU" term="%22Vermeire+S%22">Vermeire S</searchLink>; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Tilg+H%22">Tilg H</searchLink>; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Allez+M%22">Allez M</searchLink>; Université de Paris cité, INSERM U1342, Institut de Recherche Saint-Louis, Paris, France; Gastroenterology Department, Hôpital Saint-Louis, Assistance Publique -Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Verstockt+B%22">Verstockt B</searchLink>; Department of Chronic Diseases and Metabolism (CHROMETA), Katholieke Universiteit (KU) Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium. Electronic address: bram.verstockt@uzleuven.be.<br /><searchLink fieldCode="AU" term="%22Adolph+TE%22">Adolph TE</searchLink>; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: timon-erik.adolph@i-med.ac.at.
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