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Impact of voluntary exercise on obesity-induced brain pathology: Insights from a multimodal approach in male Ldlr-/-.Leiden mice.

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Title: Impact of voluntary exercise on obesity-induced brain pathology: Insights from a multimodal approach in male Ldlr-/-.Leiden mice.
Authors: Liang X; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Xiaoxue.Liang@radboudumc.nl., Lohkamp KJ; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Klara.Lohkamp@radboudumc.nl., van den Hoek AM; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands. Electronic address: a.vandenhoek@tno.nl., Geenen B; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Bram.Geenen@radboudumc.nl., Verweij V; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Vivienne.Verweij@radboudumc.nl., Morrison MC; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands. Electronic address: Martine.Morrison@tno.nl., Kleemann R; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands. Electronic address: Robert.Kleemann@tno.nl., Kiliaan AJ; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Amanda.Kiliaan@radboudumc.nl., Wiesmann M; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Maximilian.Wiesmann@radboudumc.nl., Solé-Guardia G; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands; Department of Neurology, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands. Electronic address: Gemma.SoleGuardia@radboudumc.nl.
Source: Brain, behavior, and immunity [Brain Behav Immun] 2026 Mar 17; Vol. 136, pp. 106539. Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
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  Data: Impact of voluntary exercise on obesity-induced brain pathology: Insights from a multimodal approach in male Ldlr-/-.Leiden mice.
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  Data: <searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Xiaoxue.Liang@radboudumc.nl.<br /><searchLink fieldCode="AU" term="%22Lohkamp+KJ%22">Lohkamp KJ</searchLink>; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Klara.Lohkamp@radboudumc.nl.<br /><searchLink fieldCode="AU" term="%22van+den+Hoek+AM%22">van den Hoek AM</searchLink>; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands. Electronic address: a.vandenhoek@tno.nl.<br /><searchLink fieldCode="AU" term="%22Geenen+B%22">Geenen B</searchLink>; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Bram.Geenen@radboudumc.nl.<br /><searchLink fieldCode="AU" term="%22Verweij+V%22">Verweij V</searchLink>; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Vivienne.Verweij@radboudumc.nl.<br /><searchLink fieldCode="AU" term="%22Morrison+MC%22">Morrison MC</searchLink>; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands. Electronic address: Martine.Morrison@tno.nl.<br /><searchLink fieldCode="AU" term="%22Kleemann+R%22">Kleemann R</searchLink>; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands. Electronic address: Robert.Kleemann@tno.nl.<br /><searchLink fieldCode="AU" term="%22Kiliaan+AJ%22">Kiliaan AJ</searchLink>; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Amanda.Kiliaan@radboudumc.nl.<br /><searchLink fieldCode="AU" term="%22Wiesmann+M%22">Wiesmann M</searchLink>; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands. Electronic address: Maximilian.Wiesmann@radboudumc.nl.<br /><searchLink fieldCode="AU" term="%22Solé-Guardia+G%22">Solé-Guardia G</searchLink>; Department of Medical Imaging, Anatomy, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Radboud Technology Center Preclinical imaging PRIME, Radboud Alzheimer Center, Nijmegen, the Netherlands; Department of Neurology, Research Institute for Medical Innovation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Nijmegen, the Netherlands. Electronic address: Gemma.SoleGuardia@radboudumc.nl.
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              Text: 2026 Mar 17
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