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Targeting BMP and TAZ/TEAD mechanotransduction pathways impairs acute myeloid leukemia chemoresistance.

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Title: Targeting BMP and TAZ/TEAD mechanotransduction pathways impairs acute myeloid leukemia chemoresistance.
Authors: Barral L; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France., Lespinasse N; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France., Martin Cardozo C; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Univ Lyon, UCBL, INSA Lyon, ECL, CNRS, CPE Lyon, INL, UMR5270, 69622, Villeurbanne, France., Jeanpierre S; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France.; Centre Léon Bérard, 69000, Lyon, France., Bourgeois A; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France., Rösel K; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France., Beillard E; Centre Léon Bérard, 69000, Lyon, France., Laurent D; CNRS-UMR9020, INSERM-U1366, University of Lille, Lille Hospital, CRC-Lille Cancer Research Center of Lille, Lille, France., Peyrouze P; CNRS-UMR9020, INSERM-U1366, University of Lille, Lille Hospital, CRC-Lille Cancer Research Center of Lille, Lille, France., Belhabri A; Centre Léon Bérard, 69000, Lyon, France., Guillermin Y; Centre Léon Bérard, 69000, Lyon, France., Mazurier F; Univ. Rennes, CNRS, Inserm, IGDR (Institut de Génétique et Développement de Rennes), UMR6290, ERL U1305, 35000, Rennes, France., Cheok M; CNRS-UMR9020, INSERM-U1366, University of Lille, Lille Hospital, CRC-Lille Cancer Research Center of Lille, Lille, France., Audry-Deschamps MC; Univ Lyon, UCBL, INSA Lyon, ECL, CNRS, CPE Lyon, INL, UMR5270, 69622, Villeurbanne, France., Faivre M; Univ Lyon, UCBL, INSA Lyon, ECL, CNRS, CPE Lyon, INL, UMR5270, 69622, Villeurbanne, France., Maguer-Satta V; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France.; Univ Lyon, UCBL, INSA Lyon, ECL, CNRS, CPE Lyon, INL, UMR5270, 69622, Villeurbanne, France., Lefort S; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France. sylvain.lefort@lyon.unicancer.fr.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France. sylvain.lefort@lyon.unicancer.fr.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France. sylvain.lefort@lyon.unicancer.fr.
Source: Leukemia [Leukemia] 2026 Jun; Vol. 40 (6), pp. 1151-1162. Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: Targeting BMP and TAZ/TEAD mechanotransduction pathways impairs acute myeloid leukemia chemoresistance.
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  Data: <searchLink fieldCode="AU" term="%22Barral+L%22">Barral L</searchLink>; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Lespinasse+N%22">Lespinasse N</searchLink>; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Martin+Cardozo+C%22">Martin Cardozo C</searchLink>; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Univ Lyon, UCBL, INSA Lyon, ECL, CNRS, CPE Lyon, INL, UMR5270, 69622, Villeurbanne, France.<br /><searchLink fieldCode="AU" term="%22Jeanpierre+S%22">Jeanpierre S</searchLink>; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France.; Centre Léon Bérard, 69000, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Bourgeois+A%22">Bourgeois A</searchLink>; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Rösel+K%22">Rösel K</searchLink>; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Beillard+E%22">Beillard E</searchLink>; Centre Léon Bérard, 69000, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Laurent+D%22">Laurent D</searchLink>; CNRS-UMR9020, INSERM-U1366, University of Lille, Lille Hospital, CRC-Lille Cancer Research Center of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Peyrouze+P%22">Peyrouze P</searchLink>; CNRS-UMR9020, INSERM-U1366, University of Lille, Lille Hospital, CRC-Lille Cancer Research Center of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Belhabri+A%22">Belhabri A</searchLink>; Centre Léon Bérard, 69000, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Guillermin+Y%22">Guillermin Y</searchLink>; Centre Léon Bérard, 69000, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Mazurier+F%22">Mazurier F</searchLink>; Univ. Rennes, CNRS, Inserm, IGDR (Institut de Génétique et Développement de Rennes), UMR6290, ERL U1305, 35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Cheok+M%22">Cheok M</searchLink>; CNRS-UMR9020, INSERM-U1366, University of Lille, Lille Hospital, CRC-Lille Cancer Research Center of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Audry-Deschamps+MC%22">Audry-Deschamps MC</searchLink>; Univ Lyon, UCBL, INSA Lyon, ECL, CNRS, CPE Lyon, INL, UMR5270, 69622, Villeurbanne, France.<br /><searchLink fieldCode="AU" term="%22Faivre+M%22">Faivre M</searchLink>; Univ Lyon, UCBL, INSA Lyon, ECL, CNRS, CPE Lyon, INL, UMR5270, 69622, Villeurbanne, France.<br /><searchLink fieldCode="AU" term="%22Maguer-Satta+V%22">Maguer-Satta V</searchLink>; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France.; Univ Lyon, UCBL, INSA Lyon, ECL, CNRS, CPE Lyon, INL, UMR5270, 69622, Villeurbanne, France.<br /><searchLink fieldCode="AU" term="%22Lefort+S%22">Lefort S</searchLink>; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France. sylvain.lefort@lyon.unicancer.fr.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France. sylvain.lefort@lyon.unicancer.fr.; Universite Claude Bernard Lyon 1, CRCL, 69000, Lyon, France. sylvain.lefort@lyon.unicancer.fr.
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