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Computational analysis of multi-omics data reveals CXCL10+ DC-Treg interaction drives immunosuppressive microenvironment in AFP-positive hepatocellular carcinoma.

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Title: Computational analysis of multi-omics data reveals CXCL10+ DC-Treg interaction drives immunosuppressive microenvironment in AFP-positive hepatocellular carcinoma.
Authors: Luo ZH; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China.; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China., Chen WM; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China., Yang XM; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China., Zhao J; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China., Zhang YL; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China., Huang QH; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China., Zhang MY; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China., Wang N; Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. wangna07010@163.com., Wang F; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China. wfb20042002@sina.com., Zhou J; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China. zhoujj@wust.edu.cn.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Mar 19; Vol. 83 (1). Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Computational analysis of multi-omics data reveals CXCL10<superscript>+</superscript> DC-Treg interaction drives immunosuppressive microenvironment in AFP-positive hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Luo+ZH%22">Luo ZH</searchLink>; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China.; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+WM%22">Chen WM</searchLink>; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China.<br /><searchLink fieldCode="AU" term="%22Yang+XM%22">Yang XM</searchLink>; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YL%22">Zhang YL</searchLink>; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China.<br /><searchLink fieldCode="AU" term="%22Huang+QH%22">Huang QH</searchLink>; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China.<br /><searchLink fieldCode="AU" term="%22Zhang+MY%22">Zhang MY</searchLink>; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China.<br /><searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. wangna07010@163.com.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People's Republic of China. wfb20042002@sina.com.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Biology and Genetics, The College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, China. zhoujj@wust.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2026 Mar 19; Vol. 83 (1). <i>Date of Electronic Publication: </i>2026 Mar 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00018-026-06167-4
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        Text: English
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            – D: 19
              M: 03
              Text: 2026 Mar 19
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              Y: 2026
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