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Nociceptive stimulation activates NR2B-mediated DISC1/GSK-3β and ERK/CREB signaling alleviates sevoflurane induced neurotoxicity in neonatal rats.

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Title: Nociceptive stimulation activates NR2B-mediated DISC1/GSK-3β and ERK/CREB signaling alleviates sevoflurane induced neurotoxicity in neonatal rats.
Authors: Yang TT; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China., Guo ZW; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China., Peng Y; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China., Yu W; The department of Anesthesiology, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China., Han ZQ; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China., Gao GQ; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China., Fang CF; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China., Tian H; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China., Qi SH; The department of Anesthesiology, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China., Zhang SJ; The department of Pathology, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China., Liu JR; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China. Electronic address: Jiarenliu@hrbmu.edu.cn.
Source: Neurotoxicology [Neurotoxicology] 2026 May; Vol. 114, pp. 103432. Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9711 (Electronic) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nociceptive stimulation activates NR2B-mediated DISC1/GSK-3β and ERK/CREB signaling alleviates sevoflurane induced neurotoxicity in neonatal rats.
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  Data: <searchLink fieldCode="AU" term="%22Yang+TT%22">Yang TT</searchLink>; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China.<br /><searchLink fieldCode="AU" term="%22Guo+ZW%22">Guo ZW</searchLink>; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China.<br /><searchLink fieldCode="AU" term="%22Peng+Y%22">Peng Y</searchLink>; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China.<br /><searchLink fieldCode="AU" term="%22Yu+W%22">Yu W</searchLink>; The department of Anesthesiology, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China.<br /><searchLink fieldCode="AU" term="%22Han+ZQ%22">Han ZQ</searchLink>; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China.<br /><searchLink fieldCode="AU" term="%22Gao+GQ%22">Gao GQ</searchLink>; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China.<br /><searchLink fieldCode="AU" term="%22Fang+CF%22">Fang CF</searchLink>; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China.<br /><searchLink fieldCode="AU" term="%22Tian+H%22">Tian H</searchLink>; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China.<br /><searchLink fieldCode="AU" term="%22Qi+SH%22">Qi SH</searchLink>; The department of Anesthesiology, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China.<br /><searchLink fieldCode="AU" term="%22Zhang+SJ%22">Zhang SJ</searchLink>; The department of Pathology, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China.<br /><searchLink fieldCode="AU" term="%22Liu+JR%22">Liu JR</searchLink>; The department of Clinical Laboratory, the 4th Affiliated Hospital of Harbin Medical University, 32 Yi-Yuan Street, NanGang District, Harbin 150001, China. Electronic address: Jiarenliu@hrbmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%227905589%22">Neurotoxicology</searchLink> [Neurotoxicology] 2026 May; Vol. 114, pp. 103432. <i>Date of Electronic Publication: </i>2026 Mar 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>7905589 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-9711 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220161813X%22">0161813X </searchLink><i>NLM ISO Abbreviation: </i>Neurotoxicology <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.neuro.2026.103432
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              Text: 2026 May
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