NSUN2 mediates intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling.
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| Title: | NSUN2 mediates intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling. |
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| Authors: | Bastem Akan A; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Billard CV; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Chen SY; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan City, Taiwan., Huang PH; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan City, Taiwan., Cammareri P; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Rajasekaran V; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Hall AE; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Preyzner P; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Pohl SÖ; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Farrington SM; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Dunlop MG; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Din FVN; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Myant KB; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK. kevin.myant@ed.ac.uk.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK. kevin.myant@ed.ac.uk. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Mar 19; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41856980 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: NSUN2 mediates intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bastem+Akan+A%22">Bastem Akan A</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Billard+CV%22">Billard CV</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Chen+SY%22">Chen SY</searchLink>; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+PH%22">Huang PH</searchLink>; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cammareri+P%22">Cammareri P</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Rajasekaran+V%22">Rajasekaran V</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hall+AE%22">Hall AE</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Preyzner+P%22">Preyzner P</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Pohl+SÖ%22">Pohl SÖ</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Farrington+SM%22">Farrington SM</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Dunlop+MG%22">Dunlop MG</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Din+FVN%22">Din FVN</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Myant+KB%22">Myant KB</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK. kevin.myant@ed.ac.uk.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK. kevin.myant@ed.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Mar 19; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 19. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41856980 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41419-026-08560-0 Languages: – Code: eng Text: English Titles: – TitleFull: NSUN2 mediates intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bastem Akan A – PersonEntity: Name: NameFull: Billard CV – PersonEntity: Name: NameFull: Chen SY – PersonEntity: Name: NameFull: Huang PH – PersonEntity: Name: NameFull: Cammareri P – PersonEntity: Name: NameFull: Rajasekaran V – PersonEntity: Name: NameFull: Hall AE – PersonEntity: Name: NameFull: Preyzner P – PersonEntity: Name: NameFull: Pohl SÖ – PersonEntity: Name: NameFull: Farrington SM – PersonEntity: Name: NameFull: Dunlop MG – PersonEntity: Name: NameFull: Din FVN – PersonEntity: Name: NameFull: Myant KB IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 03 Text: 2026 Mar 19 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-4889 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Cell death & disease Type: main |
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