NSUN2 mediates intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling.

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Title: NSUN2 mediates intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling.
Authors: Bastem Akan A; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Billard CV; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Chen SY; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan City, Taiwan., Huang PH; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan City, Taiwan., Cammareri P; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Rajasekaran V; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Hall AE; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Preyzner P; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Pohl SÖ; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Farrington SM; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Dunlop MG; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Din FVN; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Myant KB; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK. kevin.myant@ed.ac.uk.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK. kevin.myant@ed.ac.uk.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 19; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
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  Data: NSUN2 mediates intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling.
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  Data: <searchLink fieldCode="AU" term="%22Bastem+Akan+A%22">Bastem Akan A</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Billard+CV%22">Billard CV</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Chen+SY%22">Chen SY</searchLink>; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+PH%22">Huang PH</searchLink>; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cammareri+P%22">Cammareri P</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Rajasekaran+V%22">Rajasekaran V</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hall+AE%22">Hall AE</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Preyzner+P%22">Preyzner P</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Pohl+SÖ%22">Pohl SÖ</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Farrington+SM%22">Farrington SM</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Dunlop+MG%22">Dunlop MG</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Din+FVN%22">Din FVN</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Myant+KB%22">Myant KB</searchLink>; Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Edinburgh, UK. kevin.myant@ed.ac.uk.; Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Edinburgh, UK. kevin.myant@ed.ac.uk.
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