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Discovery of guaianolide-eudesmanolide dimers as antihepatoma agents by targeting NEURL1B to disrupt the DLL1/Notch signaling pathway.

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Title: Discovery of guaianolide-eudesmanolide dimers as antihepatoma agents by targeting NEURL1B to disrupt the DLL1/Notch signaling pathway.
Authors: Ma WJ; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China., Li QH; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China., Hu J; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China., Wang YC; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China., Ma YB; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China., Chen JJ; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China., Li TZ; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China. Electronic address: litianze@mail.kib.ac.cn.
Source: Bioorganic chemistry [Bioorg Chem] 2026 Jun 15; Vol. 174, pp. 109735. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of guaianolide-eudesmanolide dimers as antihepatoma agents by targeting NEURL1B to disrupt the DLL1/Notch signaling pathway.
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  Data: <searchLink fieldCode="AU" term="%22Ma+WJ%22">Ma WJ</searchLink>; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+QH%22">Li QH</searchLink>; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+YC%22">Wang YC</searchLink>; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ma+YB%22">Ma YB</searchLink>; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+JJ%22">Chen JJ</searchLink>; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+TZ%22">Li TZ</searchLink>; Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Natural Medicines, Kunming 650201, People's Republic of China. Electronic address: litianze@mail.kib.ac.cn.
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      – TitleFull: Discovery of guaianolide-eudesmanolide dimers as antihepatoma agents by targeting NEURL1B to disrupt the DLL1/Notch signaling pathway.
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              Text: 2026 Jun 15
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