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Hesperidin-Loaded Chitosan Nanoparticles Restore Hepatic Homeostasis by Targeting Nrf2/HO-1 and NF-κB/p53 Signaling in Malathion-Exposed Rats.

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Title: Hesperidin-Loaded Chitosan Nanoparticles Restore Hepatic Homeostasis by Targeting Nrf2/HO-1 and NF-κB/p53 Signaling in Malathion-Exposed Rats.
Authors: Elmorsy EM; Center for Health Research, Northern Border University, Arar, Saudi Arabia., Al-Ghafari AB; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.; Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia., Al Doghaither HA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Nofal W; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar, Kingdom of Saudi Arabia., Mohamed AM; Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Baiuomy AR; Department of Clinical Pharmacology, Faculty of Medicine, Taif University, Taif, Saudi Arabia., Ali SHE; Department of Pharmacology, Faculty of Medicine, Benha University, Benha, Egypt., Embaby EM; Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Source: Environmental toxicology [Environ Toxicol] 2026 Mar 20. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 100885357 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-7278 (Electronic) Linking ISSN: 15204081 NLM ISO Abbreviation: Environ Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hesperidin-Loaded Chitosan Nanoparticles Restore Hepatic Homeostasis by Targeting Nrf2/HO-1 and NF-κB/p53 Signaling in Malathion-Exposed Rats.
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  Data: <searchLink fieldCode="AU" term="%22Elmorsy+EM%22">Elmorsy EM</searchLink>; Center for Health Research, Northern Border University, Arar, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al-Ghafari+AB%22">Al-Ghafari AB</searchLink>; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.; Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al+Doghaither+HA%22">Al Doghaither HA</searchLink>; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Nofal+W%22">Nofal W</searchLink>; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar, Kingdom of Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Mohamed+AM%22">Mohamed AM</searchLink>; Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Baiuomy+AR%22">Baiuomy AR</searchLink>; Department of Clinical Pharmacology, Faculty of Medicine, Taif University, Taif, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ali+SHE%22">Ali SHE</searchLink>; Department of Pharmacology, Faculty of Medicine, Benha University, Benha, Egypt.<br /><searchLink fieldCode="AU" term="%22Embaby+EM%22">Embaby EM</searchLink>; Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
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      – TitleFull: Hesperidin-Loaded Chitosan Nanoparticles Restore Hepatic Homeostasis by Targeting Nrf2/HO-1 and NF-κB/p53 Signaling in Malathion-Exposed Rats.
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              Text: 2026 Mar 20
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