Autism spectrum disorder trios from consanguineous populations are enriched for rare homozygous variants, identifying 32 new candidate genes.
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| Title: | Autism spectrum disorder trios from consanguineous populations are enriched for rare homozygous variants, identifying 32 new candidate genes. |
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| Authors: | Harripaul R; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Rabia A; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; University of Health Sciences, Lahore, Pakistan.; CMH Lahore Medical College & Institute of Dentistry, Lahore, Pakistan., Vasli N; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Mikhailov A; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Rodrigues A; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Pastore SF; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Muhammad T; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Madanagopal TT; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Hashmi AN; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Tran C; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Stan C; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Aw K; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Zai CC; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Azam M; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan., Mahmood S; University of Health Sciences, Lahore, Pakistan.; NUR International University, Lahore, Pakistan., Heidari A; Sana Medical Genetics Laboratory, Reference Laboratory of Qazvin Medical University, Qazvin, Iran., Qamar R; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.; Science and Environment Sector, ICESCO, Rabat, Morocco., French L; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada., Tripathy S; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada., Agha Z; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.; Department of Psychiatry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA., Iqbal M; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Ghadami M; Department of Educational Sciences, Farhangian University, Tehran, Iran., Santangelo SL; Center for Clinical and Translational Research, Maine Health Institute for Research, Scarborough, ME, 04074, USA.; Department of Psychiatry, Tufts University School of Medicine, Boston, MA, 02110, USA., Bozorgmehr B; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Al Ayadhi L; Autism Research & Treatment Center, Department of Physiology, Faculty of Medicine, National Plan for Science and Technology (NPST), King Saud University, Riyadh, Saudi Arabia., Sasanfar R; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Maqbool S; The University of Child Health Sciences, Children's Hospital, Lahore, Pakistan., Hassan A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic & Translational Genetics Unit, Department of Medicine, Massachussets General Hospital, Boston, MA, USA.; University of Peshawar, Peshawar, Khyber Pakhtunkhwa, Pakistan.; Institute of Omics and Health Research, Lahore, Pakistan., Knowles JA; Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA., Ayub M; Department of Psychiatry, Queens University Kingston, Kingston, ON, Canada. m.ayub@ucl.ac.uk.; Division of Psychiatry, University College London, 149 Tottenham Ct Rd, London, W1T 7NF, UK. m.ayub@ucl.ac.uk., Vincent JB; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. john.vincent@camh.ca.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. john.vincent@camh.ca.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. john.vincent@camh.ca.; Molecular Neuropsychiatry & Development (MiND) Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), 250 College Street, Toronto, ON, M5T 1R8, Canada. john.vincent@camh.ca. |
| Source: | Scientific reports [Sci Rep] 2026 Mar 21; Vol. 16 (1). Date of Electronic Publication: 2026 Mar 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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