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Arsenic Promotes Intracellular Aβ(1-42) Accumulation via Enhanced APP but Reduced NEP Expression, and Indirectly Stimulates Extracellular Aβ Aggregation through AChE Induction in Differentiated SH-SY5Y Cells.

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Title: Arsenic Promotes Intracellular Aβ(1-42) Accumulation via Enhanced APP but Reduced NEP Expression, and Indirectly Stimulates Extracellular Aβ Aggregation through AChE Induction in Differentiated SH-SY5Y Cells.
Authors: Leelaprachakul N; Laboratory of Pharmacology, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand.; Environmental Toxicology Program, Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand., Visitnonthachai D; Laboratory of Pharmacology, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand., Niyomchan A; Department of Anatomy, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand., Maliphol K; Laboratory of Pharmacology, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand., Watcharasit P; Laboratory of Pharmacology, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand. piyajit@cri.or.th.; Environmental Toxicology Program, Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand. piyajit@cri.or.th.; Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Higher Education Science Research and Innovation, Bangkok, Thailand. piyajit@cri.or.th., Satayavivad J; Laboratory of Pharmacology, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand.; Environmental Toxicology Program, Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand.; Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Higher Education Science Research and Innovation, Bangkok, Thailand.
Source: Biological trace element research [Biol Trace Elem Res] 2026 Mar 22. Date of Electronic Publication: 2026 Mar 22.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1559-0720
DOI:10.1007/s12011-026-05075-9