DNA electroporation of HIV Env elicits robust T cell responses and memory B cell responses with muted serum antibody levels that can be boosted with recombinant protein.
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| Title: | DNA electroporation of HIV Env elicits robust T cell responses and memory B cell responses with muted serum antibody levels that can be boosted with recombinant protein. |
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| Authors: | De Rosa SC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Laboratory of Medicine and Pathology, University of Washington, Seattle, WA, USA. Electronic address: sderosa@fredhutch.org., Gravett RM; Division of Infectious Diseases, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Hahn WO; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Medicine, Division of Allergy and Infectious Disease, University of Washington, Seattle, WA, USA., Villaran M; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Huang Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA., Schmitzberger L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Montefiori D; Duke University Medical Center, Durham, NC, USA., Domin E; Duke University Medical Center, Durham, NC, USA., Tomaras GD; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Heptinstall J; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Seaton KE; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Ferrari G; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., van der Maas L; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Polakowski L; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA., Frank I; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tieu HV; Laboratory of Infectious Disease Prevention, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Kalams SA; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology, Immunology, Vanderbilt University, Nashville, TN, USA., Garcia NMG; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Huang J; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA., Ghosh S; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA., Purwar M; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA., Kulp D; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA., Humeau L; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA., Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA; Aaron Diamond AIDS Research Center and Departments of Medicine and Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Corey L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Weiner D; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA. |
| Corporate Authors: | HVTN 304 Study Team |
| Source: | Vaccine [Vaccine] 2026 Apr 19; Vol. 79, pp. 128487. Date of Electronic Publication: 2026 Mar 21. |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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