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Andrographolide induces testicular damage by triggering ferroptosis in Sertoli cells via disruption of β-TrCP-mediated ATF4 ubiquitination and degradation.

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Title: Andrographolide induces testicular damage by triggering ferroptosis in Sertoli cells via disruption of β-TrCP-mediated ATF4 ubiquitination and degradation.
Authors: Li J; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Lu Z; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Zhang N; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Zhou X; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Ma Y; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Li JQ; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Zhang Y; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Deng Z; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Lin N; Jiangsu Provincial Institute of Materia Medica, Nanjing, 210009, People's Republic of China., Yue P; Jiangsu Provincial Institute of Materia Medica, Nanjing, 210009, People's Republic of China., Yang Y; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Zhang Q; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China. Electronic address: zhangqi@njtech.edu.cn., Ma B; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China. Electronic address: mabo201012@njtech.edu.cn.
Source: Chemico-biological interactions [Chem Biol Interact] 2026 Jun 01; Vol. 432, pp. 112052. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-7786
DOI:10.1016/j.cbi.2026.112052