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Andrographolide induces testicular damage by triggering ferroptosis in Sertoli cells via disruption of β-TrCP-mediated ATF4 ubiquitination and degradation.

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Title: Andrographolide induces testicular damage by triggering ferroptosis in Sertoli cells via disruption of β-TrCP-mediated ATF4 ubiquitination and degradation.
Authors: Li J; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Lu Z; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Zhang N; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Zhou X; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Ma Y; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Li JQ; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Zhang Y; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Deng Z; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Lin N; Jiangsu Provincial Institute of Materia Medica, Nanjing, 210009, People's Republic of China., Yue P; Jiangsu Provincial Institute of Materia Medica, Nanjing, 210009, People's Republic of China., Yang Y; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China., Zhang Q; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China. Electronic address: zhangqi@njtech.edu.cn., Ma B; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China. Electronic address: mabo201012@njtech.edu.cn.
Source: Chemico-biological interactions [Chem Biol Interact] 2026 Jun 01; Vol. 432, pp. 112052. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Andrographolide induces testicular damage by triggering ferroptosis in Sertoli cells via disruption of β-TrCP-mediated ATF4 ubiquitination and degradation.
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  Data: <searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Lu+Z%22">Lu Z</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+N%22">Zhang N</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+JQ%22">Li JQ</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Deng+Z%22">Deng Z</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Lin+N%22">Lin N</searchLink>; Jiangsu Provincial Institute of Materia Medica, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yue+P%22">Yue P</searchLink>; Jiangsu Provincial Institute of Materia Medica, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China. Electronic address: zhangqi@njtech.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ma+B%22">Ma B</searchLink>; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 210009, People's Republic of China. Electronic address: mabo201012@njtech.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220227276%22">Chemico-biological interactions</searchLink> [Chem Biol Interact] 2026 Jun 01; Vol. 432, pp. 112052. <i>Date of Electronic Publication: </i>2026 Mar 20.
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