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Relationship of early rapid weight loss to efficacy and safety of tirzepatide and semaglutide for obesity: SURMOUNT-5 post hoc analysis.

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Title: Relationship of early rapid weight loss to efficacy and safety of tirzepatide and semaglutide for obesity: SURMOUNT-5 post hoc analysis.
Authors: Aronne LJ; Division of Endocrinology, Diabetes and Metabolism, Comprehensive Weight Control Center, Weill Cornell Medicine, New York, NY, USA. Electronic address: ljaronne@med.cornell.edu., Horn DB; Center for Obesity Medicine and Metabolic Performance, Department of Surgery, University of Texas McGovern Medical School, Houston, TX, USA., Kokkinos AD; First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece., Falcon BL; Eli Lilly and Company, Indianapolis, IN, USA., Wang H; TechData Service, King of Prussia, PA, USA., Hoffmann HT; Eli Lilly and Company, Indianapolis, IN, USA., Lee CJ; Eli Lilly and Company, Indianapolis, IN, USA., Dunn JP; Eli Lilly and Company, Indianapolis, IN, USA.
Source: The American journal of medicine [Am J Med] 2026 Jul; Vol. 139 (7), pp. 913-921. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0267200 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-7162 (Electronic) Linking ISSN: 00029343 NLM ISO Abbreviation: Am J Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Relationship of early rapid weight loss to efficacy and safety of tirzepatide and semaglutide for obesity: SURMOUNT-5 post hoc analysis.
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  Data: <searchLink fieldCode="AU" term="%22Aronne+LJ%22">Aronne LJ</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Comprehensive Weight Control Center, Weill Cornell Medicine, New York, NY, USA. Electronic address: ljaronne@med.cornell.edu.<br /><searchLink fieldCode="AU" term="%22Horn+DB%22">Horn DB</searchLink>; Center for Obesity Medicine and Metabolic Performance, Department of Surgery, University of Texas McGovern Medical School, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kokkinos+AD%22">Kokkinos AD</searchLink>; First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Falcon+BL%22">Falcon BL</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; TechData Service, King of Prussia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hoffmann+HT%22">Hoffmann HT</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Lee+CJ%22">Lee CJ</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Dunn+JP%22">Dunn JP</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.
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  Data: <searchLink fieldCode="JN" term="%220267200%22">The American journal of medicine</searchLink> [Am J Med] 2026 Jul; Vol. 139 (7), pp. 913-921. <i>Date of Electronic Publication: </i>2026 Mar 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Excerpta+Medica%22">Excerpta Medica </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0267200 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1555-7162 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200029343%22">00029343 </searchLink><i>NLM ISO Abbreviation: </i>Am J Med <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.amjmed.2026.03.010
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        Text: English
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      – TitleFull: Relationship of early rapid weight loss to efficacy and safety of tirzepatide and semaglutide for obesity: SURMOUNT-5 post hoc analysis.
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              Text: 2026 Jul
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              Y: 2026
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