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Exposure to per- and poly-fluoroalkyl substances and associations with embryo quality and adverse pregnancy outcomes: a prospective cohort study.

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Title: Exposure to per- and poly-fluoroalkyl substances and associations with embryo quality and adverse pregnancy outcomes: a prospective cohort study.
Authors: Wang J; Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China., Li Z; Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.; Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, Shandong, China., Hu K; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China., Hu J; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China., Jiang T; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China., Liao J; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China., Zhang Q; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China., Sun L; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China., Cui L; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China., Chen R; Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China., Ni T; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China., Zhou W; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.
Source: Frontiers in public health [Front Public Health] 2026 Mar 06; Vol. 14, pp. 1783940. Date of Electronic Publication: 2026 Mar 06 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Label: Title
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  Data: Exposure to per- and poly-fluoroalkyl substances and associations with embryo quality and adverse pregnancy outcomes: a prospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.; Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Hu+K%22">Hu K</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Jiang+T%22">Jiang T</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Liao+J%22">Liao J</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Sun+L%22">Sun L</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Cui+L%22">Cui L</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Chen+R%22">Chen R</searchLink>; Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ni+T%22">Ni T</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan, Shandong, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No. 2021RU001), Jinan, Shandong, China.
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