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Mitochondrial metabolic imbalance drives diploidization in mouse haploid embryonic stem cells via NADPH overload.

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Title: Mitochondrial metabolic imbalance drives diploidization in mouse haploid embryonic stem cells via NADPH overload.
Authors: Di Minin G; Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland. giulio.diminin@biol.ethz.ch.; Unit of Oncogenetics and Functional Oncogenomics, Centro di Riferimento Oncologico di Aviano (CRO Aviano) IRCCS, National Cancer Institute, Aviano, Italy. giulio.diminin@biol.ethz.ch., Rüegg AB; Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.; Center for Transgenic Models, University of Basel, Basel, Switzerland., Halter K; Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Fuhrer T; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland., Kleele T; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland., Zamboni N; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Wutz A; Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland. awutz@ethz.ch.
Source: Nature communications [Nat Commun] 2026 Mar 24; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Di+Minin+G%22">Di Minin G</searchLink>; Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland. giulio.diminin@biol.ethz.ch.; Unit of Oncogenetics and Functional Oncogenomics, Centro di Riferimento Oncologico di Aviano (CRO Aviano) IRCCS, National Cancer Institute, Aviano, Italy. giulio.diminin@biol.ethz.ch.<br /><searchLink fieldCode="AU" term="%22Rüegg+AB%22">Rüegg AB</searchLink>; Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.; Center for Transgenic Models, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Halter+K%22">Halter K</searchLink>; Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fuhrer+T%22">Fuhrer T</searchLink>; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kleele+T%22">Kleele T</searchLink>; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zamboni+N%22">Zamboni N</searchLink>; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wutz+A%22">Wutz A</searchLink>; Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland. awutz@ethz.ch.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Mar 24; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 24.
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