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Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200+ Egr2hi arthritogenic Th17 cells.

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Title: Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200+ Egr2hi arthritogenic Th17 cells.
Authors: Takeuchi Y; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ohara D; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.; The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan., Watanabe H; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Nishimura Y; Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Iwasaki T; The Jackson Laboratory, Bar Harbor, ME, USA.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hori S; Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan., Kawamoto H; Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Kato H; Institute of Cardiovascular Immunology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany., Kondoh G; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Morinobu A; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Mimori T; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Takeda Clinic for Rheumatic Diseases, Kyoto, Japan., Hirota K; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. hkeiji@infront.kyoto-u.ac.jp.; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan. hkeiji@infront.kyoto-u.ac.jp.; Cell Therapy Center, China Medical University Hospital, Taichung, Taiwan. hkeiji@infront.kyoto-u.ac.jp.
Source: Nature immunology [Nat Immunol] 2026 Apr; Vol. 27 (4), pp. 841-853. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200<superscript>+</superscript> Egr2<superscript>hi</superscript> arthritogenic Th17 cells.
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  Data: <searchLink fieldCode="AU" term="%22Takeuchi+Y%22">Takeuchi Y</searchLink>; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ohara+D%22">Ohara D</searchLink>; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.; The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+H%22">Watanabe H</searchLink>; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimura+Y%22">Nishimura Y</searchLink>; Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Iwasaki+T%22">Iwasaki T</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Hori+S%22">Hori S</searchLink>; Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kawamoto+H%22">Kawamoto H</searchLink>; Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+H%22">Kato H</searchLink>; Institute of Cardiovascular Immunology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kondoh+G%22">Kondoh G</searchLink>; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Morinobu+A%22">Morinobu A</searchLink>; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Mimori+T%22">Mimori T</searchLink>; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Takeda Clinic for Rheumatic Diseases, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Hirota+K%22">Hirota K</searchLink>; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. hkeiji@infront.kyoto-u.ac.jp.; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan. hkeiji@infront.kyoto-u.ac.jp.; Cell Therapy Center, China Medical University Hospital, Taichung, Taiwan. hkeiji@infront.kyoto-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2026 Apr; Vol. 27 (4), pp. 841-853. <i>Date of Electronic Publication: </i>2026 Mar 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+America+Inc%22">Nature America Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100941354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1529-2916 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215292908%22">15292908 </searchLink><i>NLM ISO Abbreviation: </i>Nat Immunol <i>Subsets: </i>MEDLINE
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