Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200+ Egr2hi arthritogenic Th17 cells.
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| Title: | Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200+ Egr2hi arthritogenic Th17 cells. |
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| Authors: | Takeuchi Y; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ohara D; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.; The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan., Watanabe H; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Nishimura Y; Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Iwasaki T; The Jackson Laboratory, Bar Harbor, ME, USA.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hori S; Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan., Kawamoto H; Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Kato H; Institute of Cardiovascular Immunology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany., Kondoh G; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Morinobu A; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Mimori T; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Takeda Clinic for Rheumatic Diseases, Kyoto, Japan., Hirota K; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. hkeiji@infront.kyoto-u.ac.jp.; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan. hkeiji@infront.kyoto-u.ac.jp.; Cell Therapy Center, China Medical University Hospital, Taichung, Taiwan. hkeiji@infront.kyoto-u.ac.jp. |
| Source: | Nature immunology [Nat Immunol] 2026 Apr; Vol. 27 (4), pp. 841-853. Date of Electronic Publication: 2026 Mar 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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