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Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in mice.

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Title: Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in mice.
Authors: Fang Y; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China., Qiu T; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China., Wang P; Department of Medical Genetics, Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Chengdu, China., Bai S; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China., Wang M; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China., Yang C; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China., Wang Y; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China., Zhang P; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China., Wang H; Department of Medical Genetics, Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Chengdu, China., Liu S; Department of Medical Genetics, Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Chengdu, China. liuxl@scu.edu.cn., Xiao X; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China. xiaoxuela@scu.edu.cn., Li Q; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China. liqintong@scu.edu.cn.
Source: The EMBO journal [EMBO J] 2026 May; Vol. 45 (9), pp. 3102-3123. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in mice.
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  Data: <searchLink fieldCode="AU" term="%22Fang+Y%22">Fang Y</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Qiu+T%22">Qiu T</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; Department of Medical Genetics, Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Bai+S%22">Bai S</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Medical Genetics, Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Medical Genetics, Prenatal Diagnostic Center, West China Second University Hospital, Sichuan University, Chengdu, China. liuxl@scu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xiao+X%22">Xiao X</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China. xiaoxuela@scu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Departments of Obstetrics & Gynecology and Pediatrics, Cancer Center, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Sichuan University, Chengdu, China. liqintong@scu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 May; Vol. 45 (9), pp. 3102-3123. <i>Date of Electronic Publication: </i>2026 Mar 23.
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        Value: 10.1038/s44318-026-00752-w
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      – TitleFull: Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in mice.
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              Text: 2026 May
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