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Mechanistic Insights into pH-Responsive Drug Release and Antitumor Effects of an Albumin-Pirarubicin Conjugate.

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Title: Mechanistic Insights into pH-Responsive Drug Release and Antitumor Effects of an Albumin-Pirarubicin Conjugate.
Authors: Tsukigawa K; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan., Imoto S; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan., Imamura K; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan., Irie N; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan., Nishi K; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan., Tokuno M; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan., Commey KL; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan., Watanabe H; Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Maruyama T; Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Otagiri M; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan., Yamasaki K; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan. kcyama@ph.sojo-u.ac.jp.; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan. kcyama@ph.sojo-u.ac.jp.
Source: Pharmaceutical research [Pharm Res] 2026 May; Vol. 43 (5), pp. 1551-1562. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Tsukigawa+K%22">Tsukigawa K</searchLink>; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.<br /><searchLink fieldCode="AU" term="%22Imoto+S%22">Imoto S</searchLink>; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.<br /><searchLink fieldCode="AU" term="%22Imamura+K%22">Imamura K</searchLink>; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.<br /><searchLink fieldCode="AU" term="%22Irie+N%22">Irie N</searchLink>; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.<br /><searchLink fieldCode="AU" term="%22Nishi+K%22">Nishi K</searchLink>; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.<br /><searchLink fieldCode="AU" term="%22Tokuno+M%22">Tokuno M</searchLink>; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.<br /><searchLink fieldCode="AU" term="%22Commey+KL%22">Commey KL</searchLink>; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+H%22">Watanabe H</searchLink>; Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.<br /><searchLink fieldCode="AU" term="%22Maruyama+T%22">Maruyama T</searchLink>; Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.<br /><searchLink fieldCode="AU" term="%22Otagiri+M%22">Otagiri M</searchLink>; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan.<br /><searchLink fieldCode="AU" term="%22Yamasaki+K%22">Yamasaki K</searchLink>; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan. kcyama@ph.sojo-u.ac.jp.; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto, 860-0082, Japan. kcyama@ph.sojo-u.ac.jp.
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        Value: 10.1007/s11095-026-04082-8
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              Text: 2026 May
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