Circulating levels of insulin-like growth factor I (IGF-I) and risk of multiple myeloma: An observational and Mendelian randomisation study.

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Title: Circulating levels of insulin-like growth factor I (IGF-I) and risk of multiple myeloma: An observational and Mendelian randomisation study.
Authors: Benavente Y; Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Public Health, Mental Health and Maternal and Child Health Nursing, Faculty of Nursing, Universitat de Barcelona, Barcelona, Spain., Hermosa S; Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Papadimitriou N; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France., Clay-Gilmour A; Department of Epidemiology & Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA., Brown EE; Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Hofmann JN; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Rothman N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Lan Q; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Purdue M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Bhatti P; Division of Population Oncology, BC Cancer, Vancouver, British Columbia, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.; Population Health Sciences, BC Cancer Research Institute, Vancouver, British Columbia, Canada., Cozen W; Division of Hematology-Oncology, Department of Medicine, University of California Irvine, Orange, California, USA., Norman A; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Slager SL; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Cerhan JR; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Rajkumar V; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Kumar SK; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Vachon CM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA., Novak AJ; Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Habermann TM; Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Link BK; Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA., Salles G; Department of Medicine, Memorial Sloan Kettering Cancer and Weill Cornell Medical College, New York, New York, USA., Ghesquieres H; Department of Hematology, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre Benite, France., Bracci PM; Department of Epidemiology and Biostatistics, UCSF, San Francisco, California, USA., Holly E; Department of Epidemiology and Biostatistics, UCSF, San Francisco, California, USA., Griffin RG; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Hildebrandt MAT; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Vermeulen RCH; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Kolijn PM; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Hjalgrim H; Haematology, Danish Cancer Institute, Danish Cancer Society, Copenhagen, Denmark.; Department of Haematology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark., Smedby KE; Department of Medicine Solna, Division of Clinical Epidemiology, Karolinska Institutet, Stockholm, Sweden.; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden., Jayasekara H; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.; School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia., Cheah S; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia., Monnereau A; Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne, Paris, France.; Paris Cité (CRESS), Université Paris Descartes, Paris, France.; Registre des Hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux, France., Chen Y; NYU Grossman School of Medicine, New York, New York, USA., Arslan A; NYU Grossman School of Medicine, New York, New York, USA., Zhang Y; Department of Cancer Prevention and Control, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Camp NJ; Huntsman Cancer Institute and Division of Hematology and Hematological Malignancies, University of Utah School of Medicine, Salt Lake City, Utah, USA., Sborov DW; Huntsman Cancer Institute and Division of Hematology and Hematological Malignancies, University of Utah School of Medicine, Salt Lake City, Utah, USA., Osman AEG; Huntsman Cancer Institute and Division of Hematology and Hematological Malignancies, University of Utah School of Medicine, Salt Lake City, Utah, USA., Ziv E; Department of Medicine, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA., De Vivo I; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Joseph V; Niehaus Center for Inherited Cancer Genomics and Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Medicine, Weill Cornell Medical College, New York, New York, USA., Teras LR; Department of Population Science, American Cancer Society, Atlanta, Georgia, USA., Patel AV; Department of Population Science, American Cancer Society, Atlanta, Georgia, USA., Kane E; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK., Vajdic CM; Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia., Guilloteau A; Registre des Hémopathies Malignes de Côte d'Or, Dijon, France.; INSERM U1231 CTM, Epi2THM Team, Université de Bourgogne, Dijon, France., Cocco P; Centre for Occupational and Environmental Health, Division of Public Health, Health Services Research Primary Care, University of Manchester, Manchester, UK.; Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy., Alemany L; Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Sainz J; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada (UGR), Granada, Spain.; Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, Spain.; Instituto de Investigación Biosanitaria IBs.Granada, Granada, Spain., McKay J; IARC, Lyon, France., Birmann BM; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Casabonne D; Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Source: British journal of haematology [Br J Haematol] 2026 Jun; Vol. 208 (6), pp. 1942-1953. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Circulating levels of insulin-like growth factor I (IGF-I) and risk of multiple myeloma: An observational and Mendelian randomisation study.
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  Data: <searchLink fieldCode="AU" term="%22Benavente+Y%22">Benavente Y</searchLink>; Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Public Health, Mental Health and Maternal and Child Health Nursing, Faculty of Nursing, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Hermosa+S%22">Hermosa S</searchLink>; Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Papadimitriou+N%22">Papadimitriou N</searchLink>; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Clay-Gilmour+A%22">Clay-Gilmour A</searchLink>; Department of Epidemiology & Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Brown+EE%22">Brown EE</searchLink>; Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Hofmann+JN%22">Hofmann JN</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Rothman+N%22">Rothman N</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lan+Q%22">Lan Q</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Berndt+SI%22">Berndt SI</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Albanes+D%22">Albanes D</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Purdue+M%22">Purdue M</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Machiela+MJ%22">Machiela MJ</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Chanock+SJ%22">Chanock SJ</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Bhatti+P%22">Bhatti P</searchLink>; Division of Population Oncology, BC Cancer, Vancouver, British Columbia, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.; Population Health Sciences, BC Cancer Research Institute, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Cozen+W%22">Cozen W</searchLink>; Division of Hematology-Oncology, Department of Medicine, University of California Irvine, Orange, California, USA.<br /><searchLink fieldCode="AU" term="%22Norman+A%22">Norman A</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Slager+SL%22">Slager SL</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Cerhan+JR%22">Cerhan JR</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Rajkumar+V%22">Rajkumar V</searchLink>; 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Department of Hematology, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre Benite, France.<br /><searchLink fieldCode="AU" term="%22Bracci+PM%22">Bracci PM</searchLink>; Department of Epidemiology and Biostatistics, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Holly+E%22">Holly E</searchLink>; Department of Epidemiology and Biostatistics, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Griffin+RG%22">Griffin RG</searchLink>; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Hildebrandt+MAT%22">Hildebrandt MAT</searchLink>; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Vermeulen+RCH%22">Vermeulen RCH</searchLink>; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kolijn+PM%22">Kolijn PM</searchLink>; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hjalgrim+H%22">Hjalgrim H</searchLink>; Haematology, Danish Cancer Institute, Danish Cancer Society, Copenhagen, Denmark.; Department of Haematology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Smedby+KE%22">Smedby KE</searchLink>; Department of Medicine Solna, Division of Clinical Epidemiology, Karolinska Institutet, Stockholm, Sweden.; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Jayasekara+H%22">Jayasekara H</searchLink>; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.; School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Cheah+S%22">Cheah S</searchLink>; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Monnereau+A%22">Monnereau A</searchLink>; Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne, Paris, France.; Paris Cité (CRESS), Université Paris Descartes, Paris, France.; Registre des Hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; NYU Grossman School of Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Arslan+A%22">Arslan A</searchLink>; NYU Grossman School of Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Cancer Prevention and Control, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Camp+NJ%22">Camp NJ</searchLink>; Huntsman Cancer Institute and Division of Hematology and Hematological Malignancies, University of Utah School of Medicine, Salt Lake City, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Sborov+DW%22">Sborov DW</searchLink>; Huntsman Cancer Institute and Division of Hematology and Hematological Malignancies, University of Utah School of Medicine, Salt Lake City, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Osman+AEG%22">Osman AEG</searchLink>; Huntsman Cancer Institute and Division of Hematology and Hematological Malignancies, University of Utah School of Medicine, Salt Lake City, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Ziv+E%22">Ziv E</searchLink>; Department of Medicine, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22De+Vivo+I%22">De Vivo I</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; 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Chan School of Public Health, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Joseph+V%22">Joseph V</searchLink>; Niehaus Center for Inherited Cancer Genomics and Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Medicine, Weill Cornell Medical College, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Teras+LR%22">Teras LR</searchLink>; Department of Population Science, American Cancer Society, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Patel+AV%22">Patel AV</searchLink>; Department of Population Science, American Cancer Society, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Kane+E%22">Kane E</searchLink>; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.<br /><searchLink fieldCode="AU" term="%22Vajdic+CM%22">Vajdic CM</searchLink>; Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Guilloteau+A%22">Guilloteau A</searchLink>; Registre des Hémopathies Malignes de Côte d'Or, Dijon, France.; INSERM U1231 CTM, Epi2THM Team, Université de Bourgogne, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Cocco+P%22">Cocco P</searchLink>; Centre for Occupational and Environmental Health, Division of Public Health, Health Services Research Primary Care, University of Manchester, Manchester, UK.; Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Alemany+L%22">Alemany L</searchLink>; Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sainz+J%22">Sainz J</searchLink>; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada (UGR), Granada, Spain.; Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, Spain.; Instituto de Investigación Biosanitaria IBs.Granada, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22McKay+J%22">McKay J</searchLink>; IARC, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Birmann+BM%22">Birmann BM</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Casabonne+D%22">Casabonne D</searchLink>; Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
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      – TitleFull: Circulating levels of insulin-like growth factor I (IGF-I) and risk of multiple myeloma: An observational and Mendelian randomisation study.
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          Dates:
            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1365-2141
          Numbering:
            – Type: volume
              Value: 208
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: British journal of haematology
              Type: main
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