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Flare of clonal hematopoiesis, TP53 expansion and prior melphalan drive post-CAR-T myeloid disorders in multiple myeloma.

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Title: Flare of clonal hematopoiesis, TP53 expansion and prior melphalan drive post-CAR-T myeloid disorders in multiple myeloma.
Authors: Waldschmidt J; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany. waldschmid_j@ukw.de.; Interact Advanced Clinician Scientist Program, University Hospital of Würzburg, Würzburg, Germany. waldschmid_j@ukw.de.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany. waldschmid_j@ukw.de., Fandrei D; Department of Hematology, Hemostaseology, Cellular Therapy and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany., Hecker JS; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany.; TranslaTUM, Center of Translational Cancer Research, Technical University of Munich (TUM), Munich, Germany., Meggendorfer M; MLL Munich Leukemia Laboratory, Munich, Germany., Truger M; MLL Munich Leukemia Laboratory, Munich, Germany., Reinhard F; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany., Shibru B; Department of Hematology, Hemostaseology, Cellular Therapy and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany., Högner M; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany., Gebauer A; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany., Köppel M; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany., Müller H; MLL Munich Leukemia Laboratory, Munich, Germany., Jung J; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany.; Department of Hematology and Medical Oncology, Georg August University Göttingen, Göttingen, Germany., Teschner D; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany., Topp MS; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany., Purcarea A; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany., Vučinić V; Department of Hematology, Hemostaseology, Cellular Therapy and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany., Haferlach T; MLL Munich Leukemia Laboratory, Munich, Germany., Bassermann F; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany., Platzbecker U; Department of Hematology, Hemostaseology, Cellular Therapy and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany., Einsele H; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany., Haferlach C; MLL Munich Leukemia Laboratory, Munich, Germany., Kortüm KM; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany., Metzeler KH; Department of Hematology, Hemostaseology, Cellular Therapy and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany., Merz M; Department of Hematology, Hemostaseology, Cellular Therapy and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany., Götze KS; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany., Rasche L; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Mildred-Scheel-Nachwuchszentrum, University Hospital of Würzburg, Würzburg, Germany.
Source: Leukemia [Leukemia] 2026 May; Vol. 40 (5), pp. 1054-1057. Date of Electronic Publication: 2026 Mar 24.
Publication Type: Letter
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE; In Process
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  Data: Flare of clonal hematopoiesis, TP53 expansion and prior melphalan drive post-CAR-T myeloid disorders in multiple myeloma.
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  Data: <searchLink fieldCode="AU" term="%22Waldschmidt+J%22">Waldschmidt J</searchLink>; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany. waldschmid_j@ukw.de.; Interact Advanced Clinician Scientist Program, University Hospital of Würzburg, Würzburg, Germany. waldschmid_j@ukw.de.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany. waldschmid_j@ukw.de.<br /><searchLink fieldCode="AU" term="%22Fandrei+D%22">Fandrei D</searchLink>; Department of Hematology, Hemostaseology, Cellular Therapy and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Hecker+JS%22">Hecker JS</searchLink>; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany.; TranslaTUM, Center of Translational Cancer Research, Technical University of Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Meggendorfer+M%22">Meggendorfer M</searchLink>; MLL Munich Leukemia Laboratory, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Truger+M%22">Truger M</searchLink>; MLL Munich Leukemia Laboratory, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Reinhard+F%22">Reinhard F</searchLink>; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Shibru+B%22">Shibru B</searchLink>; Department of Hematology, Hemostaseology, Cellular Therapy and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Högner+M%22">Högner M</searchLink>; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gebauer+A%22">Gebauer A</searchLink>; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; 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Department of Hematology, Hemostaseology, Cellular Therapy and Infectious Diseases, University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Götze+KS%22">Götze KS</searchLink>; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Department of Medicine III, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Rasche+L%22">Rasche L</searchLink>; Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.; Bavarian Center for Cancer Research (BZKF), Würzburg, Germany.; Mildred-Scheel-Nachwuchszentrum, University Hospital of Würzburg, Würzburg, Germany.
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